Table 1.

Summary of Mutations in the KIT Gene Found in Canine Mast Cell Tumors

MutationEquivalent Residues in Human c-Kit ProteinNo. Dogs (% of Total)*
Exon 8
    ITD417-4214188
    Q430R4271
    Total9 (4.7%)
Exon 9
    S479I4765
    N508I5053
    Total8 (4.2%)
Exon 11
    Del555-557 InsV556-5581
    Del556-5575561
    K557 InsF5581
    K557N InsP5583
    K557R Del558-5595581
    ITD571-579573-5811
    ITD571-581573-5831
    ITD571-583573-5852
    ITD571-585573-5871
    ITD571-589573-5912
    ITD572-583574-5851
    ITD572-585574-5871
    ITD572-586574-5882
    ITD572-587574-5891
    ITD572-588574-5904
    ITD572-589574-5911
    ITD572-590574-5921
    ITD573-585575-5871
    ITD573-590575-5921
    ITD573-591575-5931
    ITD575-582577-5841
    ITD576-590578-5923
    Total32 (16.8%)
Exon 17
    Del826-828 InsDT8271 (0.5%)
All mutations50 (26.2%)
  • * The cDNA for c-kit was cloned and sequenced from a total of 191 dogs.