Table 4.

Human and Rat Differentially Expressed ARE-Containing Genes

Gene SymbolGene NameRat RasV12 + TGF-β vs UntreatedHuman Stage IV vs Adenoma
AKAP7A-kinase anchor protein 7 isoform γDownDown
ANKHProgressive ankylosis protein homologueUpDown
ARL4CADP-ribosylation factor-like protein 4CUpUp
CHSY1Chondroitin sulfate synthase 1UpUp
COL14A1Collagen α-1(XIV) chain precursorDownUp
GNEBifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinaseUpDown
MBPMyelin basic proteinDownDown
RAB27ARas-related protein Rab-27ADownDown
SERPINE1Plasminogen activator inhibitor 1 precursor (PAI-1)UpUp
TFPITissue factor pathway inhibitorUpUp
VEGFAVascular endothelial growth factor AUpUp
  • NOTE: All genes listed contain AREs, are synergistically regulated by oncogenic Ras and TGF-β in RIE:iRas cells, and are significantly changed in human stage IV adenocarcinomas compared with adenomas. Presence of an ARE was determined by analysis using the ARE database ARED3.0 (35).