Table 1.

Comparison of Clinical and Other LOH Data for 11p13 LOH, LOI, and Normally Imprinted WTs

Mean Age at Diagnosis (± SD), moPStage
PRelapsed or Died, % (n)P7p LOH, % (n)P16q LOH, % (n)P
I-II, % (n)III-IV, % (n)
LOH29.4 ± 17.2 (n = 22)64 (14/22)23 (5/22)18 (4/22)14 (3/21)19 (4/21)
LOI40.8 ± 23.1 (n = 24)ns61 (14/23)17 (4/23)ns39 (9/23)ns17 (4/24)ns33 (8/24)ns
Normally imprinted54.8 ± 26.0 (n = 5)0.012 vs LOH ns vs LOI0 (0/4)100 (4/4)0.014 vs LOH 0.014 vs LOI25 (1/4)ns20 (1/5)ns20 (1/5)ns
  • NOTE: Full data for each tumor are given in Supplementary Table S1. Stage and survival data were unavailable for one LOI WT and one normally imprinted WT. Stage V tumor numbers not included in this table. Statistical analysis was by Student's t test for age at diagnosis and Fisher's exact test for other variables. Comparison is to the LOH group unless indicated otherwise. ns, nonsignificant (P > 0.017, Bonferroni's correction for multiple testing).