Table 1.

Generation of p53−/−Mdm2−/−Mdm4−/− Mice

p53−/−Mdm2−/−Mdm4+/−×p53−/−Mdm2−/−Mdm4+/−
GenotypeExpectedObserved (P = 0.78)
p53−/−Mdm2−/−Mdm4+/−67
p53−/−Mdm2−/−Mdm4+/+33
p53−/−Mdm2−/−Mdm4−/−32
p53−/−Mdm2−/−Mdm4+/−×p53−/−Mdm2−/−Mdm4−/−
GenotypeExpectedObserved (P = 0.71)
p53−/−Mdm2−/−Mdm4+/−3.54
p53−/−Mdm2−/−Mdm4−/−3.53
  • NOTE: Two different crosses were set up to examine the combined effects of Mdm2, Mdm4, and p53 loss on survival. All possible genotypes of progeny are shown. P values were determined by χ2 test.