TABLE 2.

Multiple Sequence Alignment of ZAG with Classic MHC-I–like Proteins

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  • NOTE: Conserved cysteine residues involved in disulfide linkage are shaded in black. The conserved residues predicted for peptide binding are highlighted in light gray and residues involved in β2M binding are dark gray. The sequences are as follows: ZAG, human serum ZAG (PDB: 1ZAG); MHC, class I histocompatibility antigen, HLA-A 0201 (PDB: 2CLR); HLA_A1, class I histocompatibility antigen, A-1 α chain from Homo sapiens (P30443); HLA_B7, HLA class I histocompatibility antigen, B-7 α chain from Homo sapiens (P01889); HLA_Cw2, HLA class I histocompatibility antigen, Cw-2 α chain from Homo sapiens (P30501); HLA_F, HLA class I histocompatibility antigen, α chain F from Homo sapiens (P30511); HLA_G, HLA class I histocompatibility antigen, α chain G from Homo sapiens (P17693); HLA_H, HLA class I histocompatibility antigen, α chain H from Homo sapiens (P01893); GDT, γ/δ TCR ligand (PDB: 1C16); CD1, CD1 (mouse) antigen-presenting molecule (PDB: 1CD1); FcRn (PDB: 3FRU); and HFE: HFE (human) hemochromatosis protein (PDB: 1A6Z).