TABLE 2.

miR-34a Genomic Deletion Status Correlates with miR-34a RNA Expression Levels and the Growth-inhibitory Effect of miR-34a Overexpression

Cell lineMYCNmiR-34a deletionmiR-34a levelmimic effect
SKNASNY0.00Y
IMR5YY0.05Y
NLFYY0.06Y
LAN5YY0.70Y
NB16NY1.40Y
NGPNN*0.04Y
SY5YNN20.00N
NBLSNN6.60N
SKNSHNN7.90N
SKNDZNN3.93N
  • NOTE: The designation “Y” in the appropriate columns means MYCN-amplified, miR-34a–deleted, or growth-inhibited by miR-34a overexpression. miR-34a level is quantitative measurement of endogenous miR-34a levels measured by quantitative RT-PCR normalized to the control RNU43.

  • * Allele duplicated.