Summary of the Functional MicroRNA Screen

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  • NOTE: miR-34a and miR-34c emerge as candidate tumor suppressor genes from a microRNA screen. The left half of the table summarizes the deletion (1p36, 3p22, and 11q23), gain (17q23), or amplification (MYCN) status of the cell lines used in the panel. The right half of the table summarizes the growth-inhibitory effect of the mimic or inhibitor. ā€œYā€ indicates that the growth was inhibited; ā€œNā€ indicates it was not inhibited. A yellow shaded box indicates concordance between the growth effect and the genomic status for a proposed tumor suppressor gene/oncogene and a pink box indicates discordance. Gray shading for cell lines in the secondary panel indicates that the experiment was not done.