Table 1.

Cancer Susceptibility Linked to Altered DNA Damage Responses

Cancer Susceptibility SyndromeFunctional DefectTumor Susceptibility
Fanconi's anemiaCross-link repairAcute myeloid leukemias
Ataxia-telangiectasiaDSB repair, checkpointsAcute leukemias, lymphomas
Xeroderma pigmentosumExcision repairSkin cancers
Nijmegen breakage syndromeDSB repair, checkpointsAcute leukemias, lymphomas
Li-Fraumeni (p53 heterozygosity)Cell cycle, apoptosisMany different tumors
HNPCCMismatch repairColon, uterine, others
BRCA1, BRCA2 heterozygosityDSB and other DNA repairBreast, ovary
  • Abbreviation: HNPCC, hereditary nonpolyposis colon cancer.