Table 1.

Correlation between Cell Surface Expression of Death Receptors DR4 and DR5 and Sensitivity to rhTRAIL and Its Agnostic Antibodies in Breast Cancer Cell Lines

Cell linesDR4 surface*DR5 surface*Relative sensitivity
Anti-DR4Anti-DR5rhTRAIL
MDA-MB-231+++++++++++++++
MDA-MB-468x+++++++
T47Dxx
BT549x++++++
MCF7
SKBR3x++++
BT474xx
  • * Presence (✓) or absence (x) on cell surface.

  • Apoptosis relative to MDA-MB-231 cells after treatment with the indicated agent (+, sensitive; −, resistant; data from Fig. 1A and B and data not shown for BT549).