Table 2.

Constitutive Tumorigenesis in Squamous Cell Carcinomas Affected by Major Oncogenic Pathway

Tumorigenesis5-Aza-dCPI3K Inhibitor*Erk InhibitorRapamycin
TE1+++++
TE2NA
TE4++
TE5NA
KYSE30++++
KYSE150++++
KYSE200+++++
KYSE410+++
KYSE520NA
011NA
012NA
013++NA
019+++NA
022++NA
028+++NA
Fadu+++NA
SCC15NA
  • Abbreviations: PI3K, phosphatidylinositol 3-kinase; Erk, extracellular signal–regulated kinase.

  • * LY294002 was used as a specific phosphatidylinositol 3-kinase inhibitor.

  • PD 98059 was used as a specific extracellular signal–regulated kinase inhibitor.