Table 1.

Inhibition of Osx Expression Alters Tumor Phenotype

Study Group*Blastic Lesion Incidence (%)Mixed Lesion Incidence (%)Lytic Lesion Incidence (%)Bone Lysis
Dunn8/80/80/80
Dunn-si-c6/71/70/70.07
Dunn-si-22/81/85/81.1
DLM86/82/80/80.13
DLM8-si-c8/90/91/90.11
DLM8-si-11/73/73/70.64
  • * Dunn, Dunn-si-c, Dunn-si-2, DLM8, DLM8-si-c, and DLM8-si-1 cells were injected into the left tibia of nude mice. The mice (10 per group) were sacrificed 35 d after tumor cell injection. Blastic and lytic phenotypes were determined as described in Materials and Methods.

  • P < 0.01, compared with control groups.

  • P < 0.05, compared with control groups.