Table 1.

moMETCAM/MUC18 Expression, Tumor Growth, and Pulmonary Metastasis of Five K1735 Sublines in C3H/HEN/Hsd Syngeneic Mice

Cell lines/propertiesK1735-m2K1735-4K1735-9K1735-3K1735-10References
MCAM/MUC18 expression+++++++NoneNoneNone7
Tumor size (g), after 7 d*0.05NoneNone0.05None7
Tumor size (g), after 27 d*2.7 ± 2.00.5 ± 0.220.58 ± 0.350.63 ± 0.4607
Tumor size (g), after 48 d*3.63 ± 0.43.97 ± 0.955.4 ± 5.0007
Pulmonary metastasis (no. lung nodules), after 35 dYes (>150)Yes (156)None (0)Yes (1)Yes (0.5)8
Phenotypetumor+++/met+++tumor+++/met+++tumor+++/mettumor+/metlowtumor/metlow7
  • * 1.5 × 106 cells were subcutaneously injected per mouse.

  • 1 × 105 cells were intravenously injected per mouse.