Table 2.

Selected Genes of Interest from Oligonucleotide Array-Based Expression Profiling of UWB1.289+BRCA1 Compared with UWB1.289 Cells

Gene IDGene nameDirectionGene identifierFold change +IRPFold change untreatedP
IFN-inducible genes
    IFI16IFN, γ-inducible protein 16DownAF20804317.00.0002523.70.00006
    IFI27IFN, α-inducible protein 27DownNM_0055328.30.000017.90.04150
    IFITM1IFN-induced transmembrane protein 1 (9-27)DownAA7491016.30.000264.40.04423
    IFI44IFN-induced protein 44DownNM_0064179.70.000165.60.01245
    IFI35IFN-induced protein 35DownBC0013565.60.003292.70.03976
    IFIT3IFN-induced protein with tetratricopeptide repeats 3DownAI0754073.30.000702.60.01928
    ISG20IFN-stimulated exonuclease gene 20 kDaDownU889641.90.004262.00.04224
    IFITM3IFN-induced transmembrane protein 3 (1-8U)DownBF3389471.80.000332.10.00336
    IFITM2IFN-induced transmembrane protein 2 (1-8D)DownNM_0064351.70.008492.20.00830
Genes associated with cell adhesion, invasion, and metastasis
    CLDN6Claudin 6UpAW0039296.90.000429.80.02518
    CLDN11Claudin 11 (oligodendrocyte transmembrane protein)DownAW2642045.30.000554.10.00395
    CDH6Cadherin 6, type 2, K-cadherin (fetal kidney)UpNM_0049326.20.000573.60.01399
    EDIL3EGF-like repeats and discoidin I-like domains 3UpAA05371112.90.000069.40.00476
    FLRT2Fibronectin leucine-rich transmembrane protein 2UpNM_0132312.10.003654.30.04404
    NID2Nidogen 2 (osteonidogen)UpNM_0073618.90.000036.50.01368
    RASA1RAS p21 protein activator (GTPase activating protein) 1UpM236122.10.004981.40.00375
    COL8A1Collagen, type VIII, α 1DownBE8777962.10.000462.40.03302
    ECM2Extracellular matrix protein 2, female organ and adipocyte specificDownNM_0013933.70.000294.90.00162
  • NOTE: Data are presented as genes up-regulated or down-regulated in UWB1.289+BRCA1 cells compared with UWB1.289 cells under the same condition (+IR or untreated).