Table 1.

Genes Up-Regulated and Down-Regulated at Least 3-fold in Irradiated UWB1.289+BRCA1 Cells Compared to Irradiated UWB1.289 Cells (P < 0.0005)

Gene IDGene nameGene identifierFold changeP
Genes up-regulated
    BRCA1Breast cancer 1, early onsetAF0050688.80.0018
    CLDN6Claudin 6NM_02119515.30.000010
    MGC33926Hypothetical protein MGC33926AA05883213.50.000003
    EDIL3EGF-like repeats and discoidin I-like domains 3AA05371112.90.000061
    NPR3Natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)NM_00090810.80.000214
    TIMP3TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)BF34708910.30.000142
    NID2Nidogen 2 (osteonidogen)NM_0073618.90.000026
    FLJ14054Hypothetical protein FLJ14054NM_0245638.50.000072
    PTGER2Prostaglandin E receptor 2 (subtype EP2), 53 kDaNM_0009568.50.000042
    TIMP3TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)NM_0003628.20.000079
    CLDN6Claudin 6AW0039296.90.000424
    VGLL1Vestigial like 1 (Drosophila)BE5423236.90.000011
    VGLL1Vestigial like 1 (Drosophila)NM_0162676.10.000256
    —BF3442375.60.000164
    CDH6Cadherin 6, type 2, K-cadherin (fetal kidney)BC0000195.30.000125
    CDH6Cadherin 6, type 2, K-cadherin (fetal kidney)NM_0049325.20.000157
    CDH6Cadherin 6, type 2, K-cadherin (fetal kidney)BC0000194.80.000401
    ZNF365Zinc finger protein 365NM_0149514.60.000042
    GNAQGuanine nucleotide binding protein (G protein), q polypeptideAA6284234.40.000065
    LRRN1Leucine-rich repeat neuronal 1N718744.40.000069
    —Homo sapiens, clone IMAGE:4710650, mRNABF6962164.20.000293
    ARID5BAT rich interactive domain 5B (MRF1-like)BG2850114.10.000370
    CCL2Chemokine (C-C motif) ligand 2S697384.10.000248
    GNAQGuanine nucleotide binding protein (G protein), q polypeptideBF9694284.00.000042
    SFRP1Secreted frizzled-related protein 1AF0179874.00.000023
    FZD7Frizzled homologue 7 (Drosophila)NM_0035074.00.000288
    C12orf46Chromosome 12 open reading frame 46AI0512483.90.000009
    KIAA1505Postmeiotic segregation increased 2-like 11AB0409383.80.000031
    POU3F3POU domain, class 3, transcription factor 3AW1494223.60.000014
    SFRP1Secreted frizzled-related protein 1AF0179873.60.000340
    DENND2ADENN/MADD domain containing 2AAA1276233.50.000351
    DKFZP686A01247DKFZP686A01247 hypothetical proteinAK0268153.40.000240
    TIMP3TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)U671953.40.000097
    GNAQGuanine nucleotide binding protein (G protein), q polypeptideBF2228953.30.000214
    OXTROxytocin receptorNM_0009163.30.000262
    GFBP5Insulin-like growth factor binding protein 5AW0075323.20.000106
    TPK1Thiamin pyrophosphokinase 1AB0281383.10.000011
Genes down-regulated
    IFI16INF, γ-inducible protein 16AF20804317.00.000248
    IFI16IFN, γ-inducible protein 16NM_00553116.90.000082
    IFI44IFN-induced protein 44NM_0064179.70.000162
    IFI27IFN, α-inducible protein 27NM_0055328.30.000012
    IFITM1IFN-induced transmembrane protein 1 (9-27)AA7491016.30.000264
    HHEXHomeobox, hematopoietically expressedZ215335.60.000007
    LOC151760Hypothetical LOC151760BC0385775.10.000288
    PDZK1IP1PDZK1 interacting protein 1NM_0057645.00.000001
    AOX1Aldehyde oxidase 1NM_0011594.70.000011
    SUNC1Sad1 and UNC84 domain containing 1AI2213294.40.000008
    LCP1Lymphocyte cytosolic protein 1 (L-plastin)J029234.20.000105
    PDZK1IP1PDZK1 interacting protein 1NM_0057644.00.000190
    —AL0312904.00.000050
    MX1Myxovirus (influenza virus) resistance 1, IFN-inducible protein p78 (mouse)NM_0024623.70.000174
    CDC42EP5CDC42 effector protein (Rho GTPase binding) 5AW0845443.70.000062
    ECM2Extracellular matrix protein 2, female organ and adipocyte specificNM_0013933.70.000289
    LRRC34Leucine-rich repeat containing 34AW9757723.60.000003
    PROCRProtein C receptor, endothelial (EPCR)NM_0064043.50.000338
    LRRC34Leucine-rich repeat containing 34AW9757723.50.000401
    MYLKMyosin, light polypeptide kinaseAA5268443.40.000320
    ATG3ATG3 autophagy related 3 homologue (Saccharhomyces cerevisiae)NM_0224883.40.000476
    ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif, 9AL8328353.30.000307
    —AA4703693.20.000035
    PMCHPro-melanin-concentrating hormoneAI2249773.20.000070
    VARSLValyl-tRNA synthetase likeBE2226643.20.000087
    SLC43A3Solute carrier family 43, member 3AI6301783.10.000182
  • NOTE: All cells were treated with 10 Gy IR 5 h before RNA extraction.