Table 1.

ERRα1 Relative Binding of Affinities (RBAs) for Sequences in Promoters of Human Genes Implicated in Breast Cancer

GeneLocation*Oligonucleotide SequenceRBA
PgR site 1−3,294tcctaaggactgTCAAGGTCAtcaaatacaagg1.85
ErbB2−3,441aaaggaactttcCCAAGGTCAcagagctgagct1.08
Reference ERRENAagcagtggcgatttgTCAAGGTCAcacagt1.00
PgR site 2−5,166tccttgctaaacCCAAGGTCAtaaatcttttct0.90
Erβ−559ggtgctcccactTAGAGGTCAcgcgcggcgtcg0.56
pS2 site 2−407tcccttccccctGCAAGGTCAcggtggccaccc0.50
Cathepsin D−3,635tggcatattgggTGAAGGTCAagggagtggctt0.49
IGF1R+272gctccggctcgcTGAAGGTCAcagccgaggcga0.37
Human MDM2+575gggagttcagggTAAAGGTCAcggggccggggc0.35
Prolactin−1,347caaatttgaaacTAAAGGTCAcaggctgcttta0.32
IGF2 site 2−6,479ctgtcggcaggaACAAGGTCAccccttggcgtt0.23
elk1−2,185ctcccatctcacTTAAGGTCAaagccagggtcc0.21
BRCA1−293gtaattgctgtaCGAAGGTCAgaatcgctacct0.19
aromatase−99cctgagactctaCCAAGGTCAgaaatgctgcaa0.18
PgR site 3−5,912aaaattgttttgTCTAGGTCAtttgcattttca0.14
EGF−396caaataatgggcTGAAGGTGAactatctttact0.14
pS2 site 1−266gtaggacctggaTTAAGGTCAggttggaggaga0.11
ERα−865atgtttggtatgAAAAGGTCAcattttatattc0.10
  • Abbreviation: NA, not applicable.

  • * Location of the ERRE sequence relative to the gene transcription start site.

  • Sequence found in reverse orientation in the natural promoter.