Table 2.

Protein Substrates of HDACs (Partial List)

Functional GroupProteinHDAC ImplicatedReferences
Structural proteinα-TubulinHDAC6(19)
Chaperone proteinHsp90HDAC6(84)
DNA binding nuclear receptorsAndrogen receptorHDAC1(85)
Glucocorticoid receptorHDAC2(86)
Estrogen receptor αND(87)
SHPHDAC1, HDAC3, HDAC6(88)
DNA binding transcription factorsp53HDAC1(89)
p73ND(90)
MEF2DHDAC3(91)
GCMaHDAC1, HDAC3, HDAC4, HDAC5(92)
YY1HDAC1, HDAC2, HDAC3(93)
GATA-1HDAC3, HDAC4, HDAC5(94)
GATA-2HDAC3, HDAC5(95)
GATA-3ND(96)
MyoDHDAC1(97)
E2F-1HDAC1(98)
E2F-2ND(89)
E2F-3ND(89)
RelA (in NF-κB)HDAC3(99)
PLAG1, PLAG2HDAC7(23)
Bcl-6HDAC2(100)
c-MycND(89)
EKLFND(89)
HIF-1αND(101)
Transcription coregulatorsRbND(102)
PGC-1αClass III(103)
DEKND(104)
Chromatin remodelingHMG-A1ND(105)
HMG-B1ND(105)
HMG-B2ND(105)
HMG-N2ND(106)
HMGI(Y)ND(106)
SRYHDAC3(107)
Signaling mediatorsStat3HDAC1, HDAC2, HDAC3(108)
Smad7HDAC1, HDAC3, HDAC2, HDAC5, HDAC6(109)
IRS-1ND(110)
β-CateninND(111)
DNA repair enzymesKu70ND(112)
WRNND(113)
Nuclear importImportin-α7ND(114)
  • Abbreviations: ND, not determined. HMG, high mobility group.