Table 2.

Microarray Analysis for Differentially Expressed Genes between p53WT/WT and p53Val135/WT in Early and Later Stages from Mouse Oral Tumorigenesis

GenbankGene nameSymbolFold change (P < 0.05) p53WT/WT/p53Val135/WT
NormalTumor
Apoptosis-related genes
    AB021961Transformation-related protein 53Trp53−9.6−14.6
    U75506BH3-interacting domain death agonistBid3.5−2.5
    L31532Bcl-2α gene, exon 2Bcl2−2.1
    D86353Caspase-7Casp7−2.0
    AJ224738CASP2 and RIPK1 domain containing adaptor with death domainCradd−2.4
    D84196TNFA gene for tumor necrosis factor-αTNFA−4.4
    U37522Tumor necrosis factor (ligand) superfamily, member 10Tnfsf10−2.8
    M21065IFN-regulatory factor 1Irf1−4.2
    AI853773F-box only protein 21Fbxo21−2.0
    U73037IFN-regulatory factor 7Irf7−11.5
    AV292430IFN-regulatory factor 3Irf3−2.9
    L26479Eukaryotic translation elongation factor 1 α2Eef1a2−2.3
    AF047699Fragile histidine triad geneFhit1.9
Cell cycle and growth-related genes
    X57800PCNA gene for proliferating cell nuclear antigenPcna−1.4−1.9
    U59758p53-variant (p53) mRNA−4.2−4.1
    U36760Forkhead box G1Foxg15.1−7.0
    AW048394Transformation-related protein 53-binding protein 1Trp53bp1−2.1
    AA940503Cell division cycle 23Cdc23−2.4
    AV094683Origin recognition complex, subunit 2-like (Saccharomyces cerevisiae)Orc21−3.5
    D87326Germ cell–specific gene 2Gsg2−2.8
    D87271ERK2 gene for extracellular signal-regulated kinase 2ERK22.9
    X90648v-crk sarcoma virus CT10 oncogene homologue (avian) likeCrkl−2.6
    AA089181Papillary renal cell carcinoma (translocation associated)Prcc−2.0
    U33629Myeloid ecotropic viral integration site 1Meis12.1
    X84311Cyclin A1Ccna14.6
    AI849928Cyclin D1Ccnd1−2.2
    U95826Cyclin G2Ccng22.4
    X61940Dual-specificity phosphatase 1Dusp12.6
    AV086728NIMA (never in mitosis gene a)–related expressed kinase 1Nek1−2.4
    AV138783Growth arrest and DNA damage-inducible 45βGadd45b2.7
    U60884Bridging integrator 1Bin1−2.4
    X95503Pleiomorphic adenoma gene-like 1Plagl1−2.2
    AF076845Hus1 homologue (Schizosaccharomyces pombe)Hus12.0
    AI842328Calmodulin 2Calm2−2.0
    M21828Growth arrest specific 2Gas2−2.0
    AJ010108Adenylate kinase 1Ak1−2.4
    AF043939Cell cycle regulatory transcription factor DP1 geneDP1−2.1
    U67187Regulator of G-protein signaling 2Rgs22.5
    D30782EpiregulinEreg6.0
    AI835443Brain-expressed myelocytomatosis oncogeneBmyc−2.1
    AF019249N-myc (and STAT) interactorNmi−2.2
    AB033921N-myc downstream regulated 2Ndr2−3.4
    AA833077Myc-induced nuclear antigenMina2.4
    X13945L-myc geneLmyc−2.2
    U32394Max dimerization protein 3Mad32.6
    U32395Max dimerization protein 4Mad4−2.1
    D14849Meiosis-specific nuclear structural protein 1Mns1−3.6
    AV317327Mitogen-activated protein kinase 1Mapk13.2
    D11374Signal-induced proliferation associated gene 1Sipa1−3.3
    U02487SarcospanSspn−2.2
    M95200Vascular endothelial growth factor AVegfa−3.8
    AV240218Avian reticuloendotheliosis viral (v-rel) oncogene related BRelb−2.0
    D13759Mitogen-activated protein kinase kinase kinase 8Map3k82.5
    X07750Thyroid hormone receptor αThra−2.4
    X55957Inhibin αInha−2.3
    X96639Exostoses (multiple) 1Ext1−2.6
    AI838195Opioid growth factor receptorOgfr−3.5
    X69620Inhibin β-BInhbb−5.6
    X99572c-fos-induced growth factorFigf−2.6
    M29464Platelet-derived growth factor, αPdgfa−2.0
    M37823Fibroblast growth factor-5 DNA, exon 3Fgf52.1
    U22445Thymoma viral proto-oncogene 2Akt2−2.6
    U19860Growth arrest specific 7Gas72.3
    U08337Growth differentiation factor 5Gdf52.0
    M70642Connective tissue growth factorCtgf−2.3
Small GTPase-related genes
    AI788669ADP-ribosylation factor 6Arf62.1
    AA178600Ras association (RalGDS/AF-6) domain family 2Rassf2−2.3
    AF053959Ras association (RalGDS/AF-6) domain family 5Rassf51.7
    AV345884Ral guanine nucleotide dissociation stimulatorRalgds−2.3
    X70804RAB17, member RAS oncogene familyRab17−2.6
    AW122347Rac GTPase-activating protein 1Racgap12.0
    C76597Rho GTPase-activating protein 29−4.4
    AI850288Rhophilin, Rho GTPase-binding protein 2Rhpn22.2
    U73941Rap2-interacting proteinRap2ip2.1
    AF016482Ras homologue N (RhoN)Arhn−2.1
    AV043011RAS-like, family 2, locus 9Rasl2-9−2.1
    AI838152NischarinNisch−2.0
    U53219IFN-γ-induced GTPaseIgtp−13.4
    AJ007971IFN-inducible GTPase 1Iigp1−28.8
    AJ007972IFN-inducible GTPase 2Igtp−4.5
    D50500RAB11a, member RAS oncogene familyRab11a2.3
    AW049415Ras association (RalGDS/AF-6) domain family 1Rassf1−1.4