Table 1.

CYP1B1 Tissue-Specific Expression in Hormone-Mediated Cancers and Corresponding Normal Tissue

Cancer TypeTumor Tissue*
Ref.Normal Tissue
Ref.
No. CYP1B1 Positive/No. TestedMost Common Intensity of StainingNo. CYP1B1 Positive/No. TestedMost Common Intensity of Staining
Breast
    Invasive ductal52/64Moderate to strong(4, 5)5/5Strong(6, 7)
    Invasive lobular6/8Moderate to strong(4, 5)
Uterus7/7Strong(5)
    Endometrioid carcinoma33/35Moderate to strong(147)8/9Weak(7)
Ovary7/7Strong(5)6/8Moderate(7)
    Serous cystadenocarcinoma91/99Moderate to strong(147)
    Mucinous cystadenocarcinoma20/23Strong(147)
    Clear cell adenocarcinoma6/7Weak to strong(147)
    Malignant mixed Mullerian tumor3/3Strong(147)
Prostate
    Prostate carcinoma25/33Weak to moderate(8)6/6Moderate to strong(7)
    Prostatic intraepithelial neoplasia2/2Moderate(8)
    Metaplasmic urothelium8/8Moderate to strong(8)
    Benign prostatic hyperplasia27/33Moderate(8)
Testis8/8Strong(5)NDND
  • * Assessed with various antibodies from the following publications: Murray et al. (5) and McFadyen et al. (4), which are not sensitive enough to detect CYP1B1 in normal tissues.

  • Assessed with a highly sensitive antibody developed by Tang et al. (6).

  • Expression was moderate to high in most grade 2 and 3 breast cancers.