Table 3.

Summary of Case-Control Studies Assessing CYP1B1 Polymorphisms in Relation to Cancer Risk Assessments

CancerEthnicityCase/ControlAssociation of Cancer Risk with CYP1B1 GenotypeGenotypeOR (95% CI)Ref.
Breast
    L432V*ND173/154Yes (increases risk)V/V and V/L3.30 (1.76-6.19)(14)
Mixed ancestry1,339/1,370No0.9 (0.7-1.1)(132)
Caucasian164/164No0.7 (0.4-1.5)(106)
African American59/59No1.6 (0.4-2.9)(106)
Chinese186/200Yes (increases risk)L/L2.3 (1.2-4.3)(136)
ND453/453No1.0 (0.72-1.45)(124)
Turkish84/103Yes (increases risk)V/V and V/L2.32 (1.26-4.25)(129)
Korean241/290No1.0 (0.7-1.6)(133)
Endometrial
    A119SCaucasian689/1,549No1.2 (0.9-1.4)(146)
Japanese113/202Yes (increases risk)S/S3.32 (1.38-8.01)(54)
    L432VCaucasian/African American371/420Yes (moderate increase)V/V1.34 (0.90-1.98)(145)
ND222/666No1.1 (0.75-1.59)(51)
Caucasian689/1,549No0.8 (0.7-1.0)(146)
Japanese113/202Yes (increases risk)V/V2.49 (1.10-5.66)(54)
    N453S§ND222/666Decreased riskN/S and S/S0.62 (0.42-0.91)(51)
Caucasian689/1,549No1.0 (0.8-1.3)(136)
Japanese117/200NoND(16)
Ovarian
    L432VMixed ancestry129/144Yes (increases risk)V/V3.8 (1.2-11.4)(148)
Caucasian223/280No???(149)
Prostate
    A119SJapanese117/200Yes (increases risk)S/S4.02 (1.73-9.38)(16)
    L432VJapanese136/255Yes (increases risk)V/V4.80 (1.21-19.05)(58)
Japanese117/200No1.34 (0.53-3.35)(16)
Caucasian American50/50Yes (increases risk)V/V3.3 (1.9-9.0)(154)
  • * Test for homogeneity of ORs: estimated exact Ps (Monte Carlo); P = 0.014. Data are too heterogeneous to pool. Pooled OR (95% CI), 1.08 (0.94-1.25).

  • Test for homogeneity of ORs: exact Ps (Zelen); P = 0.055. Data are marginally too heterogeneous to pool. Pooled OR (95% CI), 0.99 (0.73-1.34).

  • Test for homogeneity of ORs: exact Ps (Zelen); P = 0.18. Data are sufficiently homogeneous to pool. Pooled OR (95% CI), 0.94 (0.80-1.11); P = 0.48.

  • § Test for homogeneity of ORs: exact Ps (Zelen); P = 0.43. Data are homogeneous. Pooled OR (95% CI), 1.08 (0.72-1.63); P = 0.81.

  • Testing for homogeneity of ORs was not warranted for these data.

  • Test for homogeneity of ORs: exact Ps (Zelen); P = 0.13. Data are sufficiently homogeneous to pool. Pooled OR (95% CI), 0.43 (0.24-0.77); P = 0.0059.