Table 1.

Frequency of KIT, PDGFRA, VEGFR2, and EGFR Gene Amplifications in Gliomas at Presentation and at Recurrence

KIT, n (%)PDGFRA, n (%)VEGFR2, n (%)EGFR, n (%)
Gliomas at first diagnosis (n = 87)
    Astrocytoma (n = 38)
        Diploid or aneuploid34 (94)34 (97)30 (86)33 (100)
        Amplification2 (6)1 (3)5 (14)0 (0)
        N.A.*2335
    Anaplastic astrocytoma (n = 18)
        Diploid or aneuploid13 (72)10 (67)15 (83)15 (88)
        Amplification5 (28)5 (33)3 (17)2 (12)
        N.A.0301
    Oligodendroglioma (n = 20)
        Diploid or aneuploid18 (100)19 (100)17 (94)19 (100)
        Amplification0 (0)0 (0)1 (6)0 (0)
        N.A.2121
    Oligoastrocytoma (n = 11)
        Diploid or aneuploid8 (89)9 (100)9 (90)8 (89)
        Amplification1 (11)0 (0)1 (10)1 (11)
        N.A.2222
Recurrent gliomas (n = 87)
    Astrocytoma (n = 17)
        Diploid or aneuploid11 (85)11 (92)13 (93)11 (85)
        Amplification2 (15)1 (8)1 (7)2 (15)
        N.A.4534
    Anaplastic astrocytoma (n = 21)
        Diploid or aneuploid8 (50)15 (88)15 (88)15 (94)
        Amplification8 (50)2 (12)2 (12)1 (6)
        N.A.5445
    Oligodendroglioma (n = 17)
        Diploid or aneuploid14 (93)14 (93)14 (93)14 (93)
        Amplification1 (7)1 (7)1 (7)1 (7)
        N.A.2222
    Oligoastrocytoma (n = 16)
        Diploid or aneuploid10 (77)9 (69)8 (67)14 (100)
        Amplification3 (23)4 (31)4 (33)0 (0)
        N.A.3342
    Secondary glioblastoma (n = 16)
        Diploid or aneuploid9 (64)11 (69)14 (88)12 (86)
        Amplification5 (36)5 (31)2 (12)2 (14)
        N.A.2002
  • NOTE: Amplification analysis of all four genes was uninformative in one case of oligoastrocytoma at first diagnosis of glioma, and in three astrocytomas, four anaplastic astrocytomas, two oligodendrogliomas, and two oligoastrocytomas at tumor recurrence.

  • * Not available.