Table 1.

List of Highly Up-Regulated (>10-Fold) Genes in KIMAP Prostate Cancer Models Higher than Normal as Shown by cDNA Microarray

Gene symbolGene description20 wk60 wk
Genes related to chromosome instability
    Group 1: DNA damage checkpoint (G1 and G2)
        Brca1Breast ovarian cancer susceptibility homologue58.5566.2
        Chk1Checkpoint kinase 1 homologue (Schizosaccharomyces pombe)40.4947.1
        Rad541RAD54 like (Saccharomyces cerevisiae)28.8630.0
        Mbd4Methyl-CpG binding protein MBD426.1528.5
        Rad51ap1RAD51-associated protein 124.6541.3
        Taac3Transforming, acidic coiled coil–containing protein 324.6315.3
        E2f1E2F transcription factor 113.6716.4
        PoleDNA polymerase ϵ11.6713.5
        Oasl22-5 oligoadenylate synthetase-like 210.8315.4
    Group 2: replication checkpoint
        Cyclin B2Cyclin B87.8269.8
        Cyclin BCyclin B71.1438.6
        Rep 3Similar to replication factor C (activator 1) 340.4436.6
        mcmd5Minichromosome maintenance deficient 526.2217.9
        HcapgChromosome condensation protein G24.128.5
        Skp2S-phase kinase-associated protein 221.5720.3
        Mcmd/Mcm3Minichromosome maintenance deficient19.4312.6
        cdc6Cell division cycle 617.2214.9
        mcmd6Minichromosome maintenance deficient 515.4919.1
        ccnfCyclin F15.1713.0
        Eif4a2/repCEukaryotic translation initiation factor 4A211.9814.7
        Prc1Protein regulator of cytokinesis 111.666.79
        Cdc45lCell division cycle 4511.637.79
        Cdc2aCell division cycle 2 homologue A11.187.59
    Group 3: spindle checkpoint
        Bub1Mitotic checkpoint protein kinase60.0937.3
        Arc1Activity-regulated cytoskeletal-associated protein35.12.08
        Diap3Diaphanous homologue 327.1527.3
        Ube2cUbiquitin-conjugating enzyme E2C23.215.8
        Bub1bBudding uninhibited by benzimidazoles 1 homologue, β20.9817.1
        pttg/securinPituitary tumor transforming gene protein17.6814.9
        Klf6/Kif22Microtubule-associated motor KIF415.4817.8
        Rab6kif1Kinesin-like (Rab6kifl)15.3719.3
        spag5Sperm-associated antigen 514.7115.5
        Ranbp17RAN binding protein 1714.1910.5
        Np95Nuclear protein 9513.4618.9
        H2afx/Kif 2H2A histone family, member X13.379.59
        PimProviral integration site 112.8318.33
        RHAMMV5Hyaluronan receptor RHAMMV511.8610.69
        Hmg 2High-mobility group 2 protein11.4913.22
        Sox 4SRY-box containing gene 411.4912.58
        Usp 18Ubiquitin-specific protease 1810.7611.42
Genes related to apoptosis
    FN14Type I transmembrane protein101.450.37
    cd27Cd27 binding protein (Hindu God of destruction)50.2346.79
    Ki6724.5920.45
    Traf 4Tnf receptor-associated factor 418.8418.49
Other effector kinase, oncogenes
    Racgap1Rac GTPase-activating protein 1188.12130.32
    Mel KMaternal embryonic leucine zipper kinase54.1275.41
    EGF-BPKallikrein 938.8433.48
    GzmdGranzyme D33.89891.09
    Egr1Early-growth response 127.3610.18
    TtkTtk protein kinase22.7915.93
    ect 2ect2 oncogene18.7214.46
    PglyrpPeptidoglycan recognition protein16.9430.44
    FosFBJ osteosarcoma oncogene15.736.55
    G7eG7e protein13.5915.03
    Tmprss4Transmembrane protease, Ser413.2116.32
    Slc25a19Solute carrier family 25, member 1913.116.89
    Vig1Hemorrhagic septicemia virus (VHSV) induced gene 111.214.84
    PbkT cell–originated protein kinase/PDZ binding kinase10.827.13
    Siat7bSialyltransferase 710.293.41
Genes related to immunoresponse
    MCP-5Monocyte chemoattractant protein-5 precursor19.1128.19
    IL18BPInterleukin-18 binding protein d precursor14.4323.04
    Defcr3Defensin-related cryptdin 314.2512.61
    Igl-V1Immunoglobulin λ chain, variable 110.8177.64
    Scyb10Cytokine B subfamily (Cys-X-Cys), member 10 (Scyb10)10.155.66
Genes related to the prostate function
    GK21Glandular kallikrein 250.1927.04
    Ccsg2Germ cell-specific gene 216.4311.74
    Klk27Kallikrein 2717.299.01