Table 1.

Whole-Genome Gene Expression Study Using Affymetrix GeneChips HG-U133A and HG-U133B

Probe SetGene Title (Gene Symbol)Chromosomal LocationRelative Expression
Before AzadCAfter AzadC
202687_s_atTNF-related apoptosis-inducing ligand (TRAIL)3q26AAAA
202688_at1.02.1
231775_at*Death receptor 4 (DR4)8p21N.a.*N.a.*
209294_x_atDeath receptor 5 (DR5)8p22-p211.01.1
209295_at1.01.4
210405_x_at1.01.4
210484_s_atDecoy receptor 1 (DcR1)8p22-p21AAPA
206222_atAAPA
211163_s_atAAAA
210654_atDecoy receptor 2 (DcR2)8p21PAPA
204932_atOsteoprotegerin (OPG)8q24AAAA
204933_s_atAAAA
207686_s_atCaspase 8 (CASP8)2q33-q34AAAA
213373_s_at1.01.4
202535_atFas-associated via death domain (FADD)11q13.31.01.8
208485_x_atCASP8 and FADD-like apoptosis regulator (CFLAR, FLIP)2q33-q341.01.0
211316_x_at1.01.3
211317_s_atAAPA
211862_x_at1.01.0
1729_atTNFRSF1A-associated via death domain (TRADD)16q221.02.1
205641_s_atAAAA
204493_atBH3 interacting domain death agonist (BID)22q11.11.00.7
211725_s_at1.01.0
204413_atTNF receptor-associated factor 2 (TRAF2)9q34MAAA
203684_s_atB-cell CLL/lymphoma 2 (BCL2)18q21.3AAAA
203685_atPPMA
207004_atPMAA
207005_s_atAAAA
202763_atCaspase 3 (CASP3)4q341.01.0
209790_s_atCaspase 6 (CASP6)4q251.00.9
207181_s_atCaspase 7 (CASP7)10q251.01.2
  • NOTE: Data represent genes involved in the TRAIL-regulated apoptotic pathway with relative expression data (fold differences) before (set to 1.0) and after AzadC treatment. Relative expression is absent (A), marginal (M), and present (P) by the Affymetrix detection algorithm. Results represent means of duplicate experiments.

  • * Probe set not appropriate for DR4.