Table 2.

Correlations between 8p11-12 Amplification Determined by FISH and Histoclinical Features

No amplification,*n (%)Amplification,n (%)P
Age
    <5039 (29)18 (35)NS
    >5096 (71)34 (65)
Histologic type
    Ductal106 (79)39 (75)NS
    Lobular14 (10)3 (6)
    Other15 (11)10 (19)
Pathologic tumor size
    pT160 (44)23 (44)NS
    pT257 (42)24 (46)
    pT318 (14)5 (10)
SBR grade
    141 (30)8 (15)<0.05
    258 (43)21 (40)
    336 (27)23 (45)
Peritumoral vascular invasion
    Absent81 (60)33 (63)NS
    Present54 (40)19 (37)
Axillary lymph node status
    Negative72 (54)27 (52)NS
    Positive62 (46)25 (48)
Chemotherapy
    Yes65 (48)26 (50)NS
    No70 (52)26 (50)
Hormone therapy
    Yes28 (54)54 (41)NS
    No24 (46)76 (59)
ERBB2
    0-1109 (85)40 (87)NS
    2-319 (15)6 (13)
FGFR1
    Negative35 (32)17 (39)NS
    Positive76 (68)27 (61)
Ki-67
    <2097 (80)29 (62)<0.05
    >2024 (20)18 (38)
p53
    Negative93 (71)39 (76)NS
    Positive38 (29)12 (24)
Estrogen receptor
    Negative29 (22)12 (24)NS
    Positive103 (78)39 (76)
Progesterone receptor
    Negative44 (34)14 (29)NS
    Positive87 (76)35 (71)
  • NOTE: P4 + P5 + P6 probes. SBR, Scarf-Bloom-Richardson, histologic grade.

  • * P4 and P5 and P6 show no amplification.

  • P4 and/or P5 and/or P6 show amplification.