Table 1.

Genes with Differential Expression between Highly and Weakly Metastatic Tumors and Their Correlation to Cancer and Metastasis-Related Processes

GeneGenbank accession no.SymbolFold difference*Associated withMetastatic processes>
Human cancerHuman breast cancerMetastasisAdhesionMigrationInvasion
Cell growth and survival
Caspase recruitment domain family, member 10BG085048Card1015.33
Angiomotin-like 1AW537935Amotl18.29
Keratin complex 1, acidic, gene 18BG077966Krt1-187.31
Junction plakoglobinBG077247Jup6.68
Kruppel-like factor 4 (gut)BG069413Klf40.22
Semaphorin EBG086959Sema3c0.21
Growth arrest specific 1BG087671Gas10.09
Placenta and embryos oncofetal geneBG078428Pem0.03
Metabolism
Heat shock protein 1BG070071Hspb17.61
ATP citrate lyaseAW538652Acly5.12
S100 calcium binding protein A9 (calgranulin B)BG072801S100a94.77
Endothelin-converting enzyme 1BG083532LOC2308574.66
ATPase, Na+/K+ transporting, β1 polypeptideAW544616Atp1b14.45
Solute carrier organic anion transporter family, member 2a1BG072114Slco2a14.44
UDP-N-acetyl-α-d-galactosamine/polypeptide N-acetyl-galactosaminyltransferase 3BG068045Galnt34.39
N-acetyl-galactosaminyltransferase 3
Peptidylprolyl isomerase CBG065249Ppic0.21
Very low density lipoprotein receptorBG084234Vldlr0.10
Epoxide hydrolase 1, microsomalBG072453Ephx10.10
N-acetylated α-linked acidic dipeptidase 2BG082322Naalad20.03
Proteolysis
Serine protease inhibitor 4BG079624SPI470.77
Serine protease inhibitor, Kunitz type 1BG079254Spint125.49
Serine protease inhibitor, Kunitz type 2BG085206Spint27.02
Transglutaminase 2, C polypeptideBG074617Tgm24.23
Cell communication
POEMBG074516POEM86.33
Cell adhesion molecule-related/down-regulated by oncogenesBG088280Cdon22.52
Tumor necrosis factor receptor superfamily, member 19BG072211Tnfrsf1919.11
Protein tyrosine phosphatase, receptor type FBG088014Ptprf15.98
Anthrax toxin receptor 1BG069464Antxr19.59
PTK7 protein tyrosine kinase 7BG086779Ptk79.04
Lectin, galactose-binding,soluble 2BG074082Lgals27.00
Matrix γ-carboxyglutamate (Gla) proteinBG074366Mglap6.15
Transforming growth factor β2BG067564Tgfb25.58
F11 receptorBG075763F11r4.66
Gap junction membrane channel protein β3BG063176Gjb34.09
Myotubularin-related protein 2BG083487Mtmr24.10
Currently unknown
Glucocorticoid-induced gene 1BG070494Gig128.64
DEAH (Asp-Glu-Ala-His) box polypeptide 40BG071382Dhx4014.22
Plexin B1BG085089Plxnb18.62
Tumor protein D52-like 1BG080670Tpd52l15.47
Zinc finger protein 503BG074838Zfp5035.26
LatexinBG086942Lxn0.20
X-linked lymphocyte-regulated 3bBG081054Xlr3b0.12
G protein-coupled receptor 124BG073664Gpr1240.10
  • * Gene expression is presented as a fold difference derived by dividing the expression from highly metastatic tumors by the expression from weakly metastatic tumors. Values indicate fold expression in highly metastatic tumors.

  • Associations between individual genes and either human breast cancer, metastasis, or other human cancer was assigned (▪) by surveying current literature using a Pubmed (National Center for Biotechnology Information) search for each gene and representative category.

  • Associations between individual genes with metastatic processes were assigned (▪) by surveying current literature using a Pubmed (National Center for iotechnology Information) search for each gene and representative category.