Table 1.

p53 Gene Family

p53p63p73
DNA damage response+++−/+++
Apoptosis/cell cycle arrest++++++
Senescence++++
Developmental functionRequired for limb and skin formation; essential in stem cell biology of epitheliaRequired for central nervous system development of hippocampus, limbic telencephalon, and vomeronasal region; absence of Cajal-Retzius neurons