Table 1.

Effects of Oligoamine on Polyamine Pools, SSAT, and ODC Activities in Empty Vector and TAM67 Transfected Cells

Cell LinesTreatmentPolyamines (nmol/mg protein)
SSAT Activity (pmol/mg protein/min)ODC Activity (pmol CO2/mg protein/h)
PutrescineSpermidineSpermine
VectorControl0.5619.5012.447.93460.81
SL-11144ND5.127.2182.423.59
TAM67-21ControlND17.3813.677.49345.57
SL-11144ND4.057.4750.8610.92
  • Note: Intracellular polyamine levels, SSAT activity, and ODC activity were determined as described in “Materials and Methods” following incubation of tumor cells for 12 h in the presence of 10 μm SL-11144. Values represent the means of duplicated determinations. ND, not detected.