Table 8.

Drug Sensitivity of HL-60 AR Cells After a 48-h Serum Starvation

TreatmentAR CellsAR Cells + IGFBP-3AR Cells + IGF-IR AbAR Cells + IGF-I AbAR Cells + Isotype-Matched IgG1
None (control)14.7 ± 2.35.2 ± 2.66.1 ± 2.25.0 ± 2.315.9 ± 2.1
Camptothecin (0.1 μg/ml)20.5 ± 3.495.0 ± 9.394.2 ± 8.890.1 ± 9.422.5 ± 3.7
Etoposide (5 μg/ml)19.5 ± 1.979.5 ± 8.881.9 ± 8.683.4 ± 9.721.3 ± 2.2
Cytarabine (40 μg/ml)15.1 ± 3.375.0 ± 7.978.7 ± 7.780.4 ± 8.215.7 ± 2.9
Doxorubicin (100 μg/ml)15.8 ± 2.475.5 ± 8.881.4 ± 9.586.3 ± 9.016.9 ± 2.6
Mitoxantrone (40 μg/ml)15.7 ± 4.086.4 ± 8.987.6 ± 8.480.4 ± 9.916.4 ± 3.1
Vincristine (4 μg/ml)16.7 ± 2.780.1 ± 9.281.5 ± 8.077.8 ± 8.817.3 ± 2.3
  • Note: Cells were incubated with the drugs for 6 h. The results show the percentage of apoptotic cells and are the means ± SD of three separate experiments.