Table 7.

Rapamycin Does Not Enhance the Sensitivity of HL-60 AR Cells to Apoptosis Inducers

Cell TreatmentPercentage of Apoptotic Cells
None (control)1.8 ± 0.9
Rapamycin alone2.9 ± 1.2
Rapamycin + camptothecin (0.1 μg/ml)2.7 ± 1.4
Rapamycin + etoposide (5 μg/ml)3.4 ± 1.6
Rapamycin + doxorubicin (100 μg/ml)3.6 ± 1.5
Rapamycin + cytarabine (40 μg/ml)2.8 ± 1.7
Rapamycin + mitoxantrone (40 μg/ml)3.0 ± 1.5
Rapamycin + vincristine (4 μg/ml)3.4 ± 1.9
  • Note: The data are the means ± SD from three separate experiments. Cells were exposed to the drugs for 24 h.