Table 2.

Effect of Oral ST1481, Delivered qdx5/wx2w, on MeWo Melanoma Xenograft

DrugDose (mg/kg)Vascular Areaa
%mm2
10% DMSO7.8 ± 0.298.55 ± 0.31
ST14810.064.8 ± 0.55*5.24 ± 0.60*
ST14810.123.5 ± 0.33**3.82 ± 0.36**
  • a Vascular area was calculated as described in “Materials and Methods,” 14 days after tumor inoculum. Mean ± SE.

  • * P < 0.01 versus control mice, by the Mann-Whitney test.

  • ** P < 0.001 versus control mice, by the Mann-Whitney test.