Table 2.

Gene Ontology pathways overrepresented in the list of NFBD1 shRNA-regulated genes

PExpCountCountTerm
016Energy derivation by oxidation of organic compounds
0.00103Tricarboxylic acid cycle
0.00103Acetyl-CoA catabolic process
0.001311Carbohydrate metabolic process
0.00129Cellular carbohydrate metabolic process
0.00103Coenzyme catabolic process
0.00103Acetyl-CoA metabolic process
0.00102Visual learning
0.00203Cofactor catabolic process
0.00203Aerobic respiration
0.00302Visual behavior
0.00303Glycogen metabolic process
0.00414Response to light stimulus
0.00403Glucan metabolic process
0.00403Cellular respiration
0.00426Generation of precursor metabolites and energy
0.00503Energy reserve metabolic process
0.00602Vesicle organization and biogenesis
0.00801Positive regulation of T cell mediated cytotoxicity
0.00801Vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure
0.00801Regulation of glycogen catabolic process
0.00801Succinyl-CoA pathway
0.00801Response to isoquinoline alkaloid
0.00801Positive regulation of mRNA 3/-end processing
0.00801Tyrosine phosphorylation of Stat4 protein
0.00801Regulation of tyrosine phosphorylation of Stat4 protein
0.00801Positive regulation of tyrosine phosphorylation of Stat4 protein
0.00801Response to morphine
0.00801Negative regulation of glycogen catabolic process
0.00801Positive regulation of glycogen catabolic process
0.00801Positive regulation of mRNA processing
0.00802Learning
0.00802Regulation of blood coagulation
0.00926RNA splicing
0.00914Response to radiation
0.00902Tricarboxylic acid cycle intermediate metabolic process

NOTE: The list of NFBD1 shRNA-regulated genes in the absence of IR was compared with lists of genes grouped by pathways in the Gene Ontology database. The expected number of genes regulated by chance in each pathway was compared with the actual number of genes regulated by NFBD1 shRNA. Overrepresented pathways are listed.