Table 1.

List of Achilles' heel targets identified by HT-RNAi screening

SymbolGene nameReferencesa
AKAP3A-kinase anchor protein 110 kDa
AKAP9A-kinase anchor protein 350 kDa
ALS2CR7Cyclin-dependent kinase 15
CALM1Calmodulin 1 (phosphorylase kinase, delta)(16)
CDK5R2Cyclin-dependent kinase 5, regulatory subunit 2(17, 18)
EPHA5Ephrin type-A receptor 5
FLT4Fms-like tyrosine kinase 4(19)
GRK4G protein-coupled receptor kinase 4
HK1Hexokinase 1(20)
MAP2K1IP1MAPK scaffold protein 1
MAPK11MAP kinase p38 beta(21–24)
NEK3NIMA (never in mitosis gene a)-related kinase 3
PLK3Polo-like kinase 3 (Drosophila)
PRKCL1Protein-kinase C-related kinase 1
PRKYProtein kinase, Y-linked
PTK9Twinfilin, actin-binding protein, homolog 1 (Drosophila)
PTK9LTwinfilin, actin-binding protein, homolog 2 (Drosophila)
ROR2Receptor tyrosine kinase-like orphan receptor 2(25)
STK10Serine/threonine kinase 10, Lymphocyte-oriented kinase(26)
TAOK3TAO kinase 3
TNK1Tyrosine kinase, nonreceptor, 1
TNK2Tyrosine kinase, nonreceptor, 2

NOTE: A selection of genes that, when knocked down by RNAi, decrease the viability of pancreatic cancer cells.

  • aA selection of references related to the gene target in pancreatic cancer.