Table 4.

Presence of selective MMPs and TIMP1–4 transcripts in the FTC-133–EGFP and RLN2 stable transfectants

MMP
MMP1Negative
MMP2Upregulated in RLN2 clones
MMP3Negative
MMP8Negative
MMP9Negative
MMP10Negative
MMP13Present but unchanged
MMP14Upregulated in RLN2 clones
TIMP
TIMP1Present but unchanged
TIMP2Present but unchanged
TIMP3Downregulated in RLN2 clones
TIMP4Present but unchanged

NOTE: EGFP and RLN2 transfectants showed similar mRNA profiles, whereas quantitative differences were obtained for MMP2, MT1-MMP, and TIMP3, with the 2 MMPs being upregulated and TIMP3 downregulated in RLN2 clones. MMP13 (collagenase-3) transcripts were not altered between RLN2 and EGFP clones.