PT  - JOURNAL ARTICLE
AU  - Sissung, Tristan M.
AU  - Price, Douglas K.
AU  - Sparreboom, Alex
AU  - Figg, William D.
TI  - Pharmacogenetics and Regulation of Human Cytochrome <em>P</em>450 1B1: Implications in Hormone-Mediated Tumor Metabolism and a Novel Target for Therapeutic Intervention
AID  - 10.1158/1541-7786.MCR-05-0101
DP  - 2006 Mar 01
TA  - Molecular Cancer Research
PG  - 135--150
VI  - 4
IP  - 3
4099  - http://mcr.aacrjournals.org/content/4/3/135.short
4100  - http://mcr.aacrjournals.org/content/4/3/135.full
SO  - Mol Cancer Res2006 Mar 01; 4
AB  - Several of the hormone-mediated cancers (breast, endometrial, ovarian, and prostate) represent major cancers in both incidence and mortality rates. The etiology of these cancers is in large part modulated by the hormones estrogen and testosterone. As advanced disease develops, the common treatment for these cancers is chemotherapy. Thus, genes that can alter tissue response to hormones and alter clinical response to chemotherapy are of major interest. The cytochrome P450 1B1 (CYP1B1) may be involved in disease progression and modulate the treatment in the above hormone-mediated cancers. This review will focus on the pharmacogenetics of CYP1B1 in relation to hormone-mediated cancers and provide an assessment of cancer risk based on CYP1B1 polymorphisms and expression. In addition, it will provide a summary of CYP1B1 gene regulation and expression in normal and neoplastic tissue. (Mol Cancer Res 2006;4(3):1–16)