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Cell Fate Decisions

Palbociclib Renders Human Papilloma Virus–Negative Head and Neck Squamous Cell Carcinoma Vulnerable to the Senolytic Agent Navitoclax

Nicholas J. Gadsden, Cory D. Fulcher, Daniel Li, Nitisha Shrivastava, Carlos Thomas, Jeffrey E. Segall, Michael B. Prystowsky, Nicolas F. Schlecht, Evripidis Gavathiotis and Thomas J. Ow
Nicholas J. Gadsden
1Department of Anesthesiology, Columbia University, New York, New York.
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Cory D. Fulcher
2Department of Otorhinolaryngology—Head and Neck Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York.
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Daniel Li
3Medical Student, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York.
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Nitisha Shrivastava
4Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York.
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Carlos Thomas
4Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York.
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Jeffrey E. Segall
4Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York.
5Department of Anatomy and Structural Biology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York.
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  • ORCID record for Jeffrey E. Segall
Michael B. Prystowsky
4Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York.
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Nicolas F. Schlecht
4Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York.
6Division of Oral Health and Society, Faculty of Dentistry, McGill University, Montreal, Canada.
7Department of Epidemiology and Population Health, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York.
8Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
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Evripidis Gavathiotis
9Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York.
10Department of Medicine (Cardiology), Albert Einstein College of Medicine, Bronx, New York.
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Thomas J. Ow
2Department of Otorhinolaryngology—Head and Neck Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York.
4Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York.
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  • For correspondence: thow@montefiore.org
DOI: 10.1158/1541-7786.MCR-20-0915
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Article Information

DOI 
https://doi.org/10.1158/1541-7786.MCR-20-0915
PubMed 
33495400

Published By 
American Association for Cancer Research
Print ISSN 
1541-7786
Online ISSN 
1557-3125
History 
  • Received October 15, 2020
  • Revision received December 6, 2020
  • Accepted January 19, 2021
  • Published first January 25, 2021.

Article Versions

  • Previous version (January 25, 2021 - 05:51).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2021 American Association for Cancer Research.

Author Information

  1. Nicholas J. Gadsden1,
  2. Cory D. Fulcher2,
  3. Daniel Li3,
  4. Nitisha Shrivastava4,
  5. Carlos Thomas4,
  6. Jeffrey E. Segall4,5,
  7. Michael B. Prystowsky4,
  8. Nicolas F. Schlecht4,6,7,8,
  9. Evripidis Gavathiotis9,10, and
  10. Thomas J. Ow2,4,*
  1. 1Department of Anesthesiology, Columbia University, New York, New York.
  2. 2Department of Otorhinolaryngology—Head and Neck Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York.
  3. 3Medical Student, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York.
  4. 4Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York.
  5. 5Department of Anatomy and Structural Biology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York.
  6. 6Division of Oral Health and Society, Faculty of Dentistry, McGill University, Montreal, Canada.
  7. 7Department of Epidemiology and Population Health, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York.
  8. 8Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
  9. 9Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York.
  10. 10Department of Medicine (Cardiology), Albert Einstein College of Medicine, Bronx, New York.
  1. ↵*Corresponding Author:
    Thomas J. Ow, Otorhinoloaryngology—Head and Neck Surgery, Albert Einstein College of Medicine, 3400 Bainbridge Avenue, Bronx, NY 10467. Phone: 718-920-8488; E-mail: thow{at}montefiore.org
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doi: 10.1158/1541-7786.MCR-20-0915

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Palbociclib Renders Human Papilloma Virus–Negative Head and Neck Squamous Cell Carcinoma Vulnerable to the Senolytic Agent Navitoclax
Nicholas J. Gadsden, Cory D. Fulcher, Daniel Li, Nitisha Shrivastava, Carlos Thomas, Jeffrey E. Segall, Michael B. Prystowsky, Nicolas F. Schlecht, Evripidis Gavathiotis and Thomas J. Ow
Mol Cancer Res February 16 2021 DOI: 10.1158/1541-7786.MCR-20-0915

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Palbociclib Renders Human Papilloma Virus–Negative Head and Neck Squamous Cell Carcinoma Vulnerable to the Senolytic Agent Navitoclax
Nicholas J. Gadsden, Cory D. Fulcher, Daniel Li, Nitisha Shrivastava, Carlos Thomas, Jeffrey E. Segall, Michael B. Prystowsky, Nicolas F. Schlecht, Evripidis Gavathiotis and Thomas J. Ow
Mol Cancer Res February 16 2021 DOI: 10.1158/1541-7786.MCR-20-0915
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