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Metabolism

Metabolomics of Prostate Cancer Gleason Score in Tumor Tissue and Serum

Kathryn L. Penney, Svitlana Tyekucheva, Jacob Rosenthal, Habiba El Fandy, Ryan Carelli, Stephanie Borgstein, Giorgia Zadra, Giuseppe Nicolò Fanelli, Lavinia Stefanizzi, Francesca Giunchi, Mark Pomerantz, Samuel Peisch, Hannah Coulson, Rosina Lis, Adam S. Kibel, Michelangelo Fiorentino, Renato Umeton and Massimo Loda
Kathryn L. Penney
1Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
2Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
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Svitlana Tyekucheva
3Department of Data Sciences, Dana-Farber Cancer Institute, Boston, Massachusetts.
4Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
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  • ORCID record for Svitlana Tyekucheva
Jacob Rosenthal
4Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
5Department of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Habiba El Fandy
6Department of Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts.
7Department of Pathology, NCI, Cairo University, Giza, Egypt.
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Ryan Carelli
8Department of Pathology and Laboratory Medicine, Weill Cornell Medicine and the New York Genome Center, New York, New York.
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Stephanie Borgstein
6Department of Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Giorgia Zadra
6Department of Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Giuseppe Nicolò Fanelli
9Division of Pathology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
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  • ORCID record for Giuseppe Nicolò Fanelli
Lavinia Stefanizzi
10Department of Diagnostics and Public Health, University and Hospital Trust of Verona, Verona, Italy.
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Francesca Giunchi
11Metropolitan Department of Pathology, University of Bologna, Bologna, Italy.
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Mark Pomerantz
12Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Samuel Peisch
2Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
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Hannah Coulson
13Department of Pathology, Brigham & Women's Hospital, Boston, Massachusetts.
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Rosina Lis
12Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Adam S. Kibel
14Division of Urology, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
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Michelangelo Fiorentino
11Metropolitan Department of Pathology, University of Bologna, Bologna, Italy.
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Renato Umeton
4Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
5Department of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, Massachusetts.
15Massachusetts Institute of Technology, Cambridge, Massachusetts.
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Massimo Loda
8Department of Pathology and Laboratory Medicine, Weill Cornell Medicine and the New York Genome Center, New York, New York.
16The Broad Institute, Cambridge, Massachusetts.
17Harvard Medical School, Boston, Massachusetts.
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  • For correspondence: mloda@med.cornell.edu
DOI: 10.1158/1541-7786.MCR-20-0548
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Article Information

DOI 
https://doi.org/10.1158/1541-7786.MCR-20-0548
PubMed 
33168599

Published By 
American Association for Cancer Research
Print ISSN 
1541-7786
Online ISSN 
1557-3125
History 
  • Received June 18, 2020
  • Revision received September 2, 2020
  • Accepted November 3, 2020
  • Published first November 9, 2020.

Article Versions

  • Previous version (November 9, 2020 - 05:29).
  • Previous version (November 13, 2020 - 07:03).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2020 American Association for Cancer Research.

Author Information

  1. Kathryn L. Penney1,2,#,
  2. Svitlana Tyekucheva3,4,#,
  3. Jacob Rosenthal4,5,
  4. Habiba El Fandy6,7,
  5. Ryan Carelli8,
  6. Stephanie Borgstein6,
  7. Giorgia Zadra6,
  8. Giuseppe Nicolò Fanelli9,
  9. Lavinia Stefanizzi10,
  10. Francesca Giunchi11,
  11. Mark Pomerantz12,
  12. Samuel Peisch2,
  13. Hannah Coulson13,
  14. Rosina Lis12,
  15. Adam S. Kibel14,
  16. Michelangelo Fiorentino11,
  17. Renato Umeton4,5,15, and
  18. Massimo Loda8,16,17,*
  1. 1Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
  2. 2Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
  3. 3Department of Data Sciences, Dana-Farber Cancer Institute, Boston, Massachusetts.
  4. 4Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
  5. 5Department of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, Massachusetts.
  6. 6Department of Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  7. 7Department of Pathology, NCI, Cairo University, Giza, Egypt.
  8. 8Department of Pathology and Laboratory Medicine, Weill Cornell Medicine and the New York Genome Center, New York, New York.
  9. 9Division of Pathology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
  10. 10Department of Diagnostics and Public Health, University and Hospital Trust of Verona, Verona, Italy.
  11. 11Metropolitan Department of Pathology, University of Bologna, Bologna, Italy.
  12. 12Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  13. 13Department of Pathology, Brigham & Women's Hospital, Boston, Massachusetts.
  14. 14Division of Urology, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
  15. 15Massachusetts Institute of Technology, Cambridge, Massachusetts.
  16. 16The Broad Institute, Cambridge, Massachusetts.
  17. 17Harvard Medical School, Boston, Massachusetts.
  1. ↵*Corresponding Author:
    Massimo Loda, Weill Cornell Medicine, New York Presbyterian-Weill Cornell Campus, 1300 York Avenue, Room C-302, New York, NY 10065. Phone: 212-746-6464; Fax: 212-746-8192; E-mail: mloda{at}med.cornell.edu
  1. ↵#K.L. Penney and S. Tyekucheva contributed equally to this article.

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Metabolomics of Prostate Cancer Gleason Score in Tumor Tissue and Serum
Kathryn L. Penney, Svitlana Tyekucheva, Jacob Rosenthal, Habiba El Fandy, Ryan Carelli, Stephanie Borgstein, Giorgia Zadra, Giuseppe Nicolò Fanelli, Lavinia Stefanizzi, Francesca Giunchi, Mark Pomerantz, Samuel Peisch, Hannah Coulson, Rosina Lis, Adam S. Kibel, Michelangelo Fiorentino, Renato Umeton and Massimo Loda
Mol Cancer Res December 18 2020 DOI: 10.1158/1541-7786.MCR-20-0548

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Metabolomics of Prostate Cancer Gleason Score in Tumor Tissue and Serum
Kathryn L. Penney, Svitlana Tyekucheva, Jacob Rosenthal, Habiba El Fandy, Ryan Carelli, Stephanie Borgstein, Giorgia Zadra, Giuseppe Nicolò Fanelli, Lavinia Stefanizzi, Francesca Giunchi, Mark Pomerantz, Samuel Peisch, Hannah Coulson, Rosina Lis, Adam S. Kibel, Michelangelo Fiorentino, Renato Umeton and Massimo Loda
Mol Cancer Res December 18 2020 DOI: 10.1158/1541-7786.MCR-20-0548
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