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Molecular Cancer Research
Molecular Cancer Research

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Treating Cancer as an Invasive Species

Javad Noorbakhsh, Zi-Ming Zhao, James C Russell and Jeffrey H Chuang
Javad Noorbakhsh
N/A, The Jackson Laboratory for Genomic Medicine
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Zi-Ming Zhao
Computational Biology, Jackson Lab Genomic Medicine
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James C Russell
University of Auckland
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Jeffrey H Chuang
Computational Biology, The Jackson Laboratory for Genomic Medicine
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  • ORCID record for Jeffrey H Chuang
  • For correspondence: jeff.chuang@jax.org
DOI: 10.1158/1541-7786.MCR-19-0262
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Abstract

To cure a patient's cancer is to eradicate invasive cells from the ecosystem of the body. However, the ecological complexity of this challenge is not well understood. Here we show how results from eradications of invasive mammalian species from islands-one of the few contexts in which invasive species have been regularly cleared-inform new research directions for treating cancer. We first summarize the epidemiological characteristics of island invader eradications and cancer treatments by analyzing recent datasets from the Database of Invasive Island Species Eradications and The Cancer Genome Atlas, detailing the superior successes of island eradication projects. Next, we compare how genetic and environmental factors impact success in each system. These comparisons illuminate a number of promising cancer research and treatment directions, such as heterogeneity engineering as motivated by gene drives and adaptive therapy; multi-scale analyses of how population heterogeneity potentiates treatment resistance; and application of ecological data mining techniques to high-throughput cancer data. We anticipate that interdisciplinary comparisons between tumor progression and invasive species would inspire development of novel paradigms to cure cancer.

  • Received March 15, 2019.
  • Revision received June 26, 2019.
  • Accepted September 10, 2019.
  • Copyright ©2019, American Association for Cancer Research.

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Published OnlineFirst September 16, 2019
doi: 10.1158/1541-7786.MCR-19-0262

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Treating Cancer as an Invasive Species
Javad Noorbakhsh, Zi-Ming Zhao, James C Russell and Jeffrey H Chuang
Mol Cancer Res September 16 2019 DOI: 10.1158/1541-7786.MCR-19-0262

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Treating Cancer as an Invasive Species
Javad Noorbakhsh, Zi-Ming Zhao, James C Russell and Jeffrey H Chuang
Mol Cancer Res September 16 2019 DOI: 10.1158/1541-7786.MCR-19-0262
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Molecular Cancer Research
eISSN: 1557-3125
ISSN: 1541-7786

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