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Molecular Cancer Research
Molecular Cancer Research

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Tumor Microenvironment and Immunobiology

Proinflammatory Macrophages Promote Multiple Myeloma Resistance to Bortezomib Therapy

Ofrat Beyar-Katz, Ksenia Magidey, Anat Reiner-Benaim, Noga Barak, Irit Avivi, Yael Cohen, Michael Timaner, Shimrit Avraham, Michal Hayun, Noa Lavi, Marina Bersudsky, Elena Voronov, Ron N. Apte and Yuval Shaked
Ofrat Beyar-Katz
Cell Biology and Cancer Science, Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel.Hematology and Bone Marrow Transplantation Department, Rambam Health Care Campus, Haifa, Israel.
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Ksenia Magidey
Cell Biology and Cancer Science, Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel.
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Anat Reiner-Benaim
Clinical Epidemiology Unit, Rambam Health Care Campus, Haifa, Israel.
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Noga Barak
Cell Biology and Cancer Science, Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel.
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Irit Avivi
Hematology and Bone Marrow Transplantation Department, Ichilov Medical Center, Tel Aviv, Israel.
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Yael Cohen
Hematology and Bone Marrow Transplantation Department, Ichilov Medical Center, Tel Aviv, Israel.
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Michael Timaner
Cell Biology and Cancer Science, Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel.
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Shimrit Avraham
Cell Biology and Cancer Science, Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel.
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Michal Hayun
Hematology Research Center, Rambam Health Care Campus, Haifa, Israel.
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Noa Lavi
Hematology and Bone Marrow Transplantation Department, Rambam Health Care Campus, Haifa, Israel.
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Marina Bersudsky
The Shraga Segal Department of Microbiology, Immunonology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
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Elena Voronov
The Shraga Segal Department of Microbiology, Immunonology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
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Ron N. Apte
The Shraga Segal Department of Microbiology, Immunonology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
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Yuval Shaked
Cell Biology and Cancer Science, Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel.
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  • For correspondence: yshaked@technion.ac.il
DOI: 10.1158/1541-7786.MCR-19-0487
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    • Supplementary Data - Figure S1. Bone marrow-derived macrophages enrich MM TICs. Figure S2. IL-1β promotes MM-TIC enrichment. Figure S3. Reduced survival in MM patients with high levels of M1 pro-inflammatory macrophages and TICs. Table S1: Patient characteristics and treatment description Table S2. Panel of antibodies and isotype conjugates used in CyTOF.
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Published OnlineFirst September 10, 2019
doi: 10.1158/1541-7786.MCR-19-0487

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Proinflammatory Macrophages Promote Multiple Myeloma Resistance to Bortezomib Therapy
Ofrat Beyar-Katz, Ksenia Magidey, Anat Reiner-Benaim, Noga Barak, Irit Avivi, Yael Cohen, Michael Timaner, Shimrit Avraham, Michal Hayun, Noa Lavi, Marina Bersudsky, Elena Voronov, Ron N. Apte and Yuval Shaked
Mol Cancer Res September 10 2019 DOI: 10.1158/1541-7786.MCR-19-0487

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Proinflammatory Macrophages Promote Multiple Myeloma Resistance to Bortezomib Therapy
Ofrat Beyar-Katz, Ksenia Magidey, Anat Reiner-Benaim, Noga Barak, Irit Avivi, Yael Cohen, Michael Timaner, Shimrit Avraham, Michal Hayun, Noa Lavi, Marina Bersudsky, Elena Voronov, Ron N. Apte and Yuval Shaked
Mol Cancer Res September 10 2019 DOI: 10.1158/1541-7786.MCR-19-0487
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Molecular Cancer Research
eISSN: 1557-3125
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