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Angiogenesis, Metastasis, and the Cellular Microenvironment

Fibulin-3 Is Uniquely Upregulated in Malignant Gliomas and Promotes Tumor Cell Motility and Invasion

Bin Hu, Keerthi K. Thirtamara-Rajamani, Hosung Sim and Mariano S. Viapiano
Bin Hu
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Keerthi K. Thirtamara-Rajamani
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Hosung Sim
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Mariano S. Viapiano
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DOI: 10.1158/1541-7786.MCR-09-0207
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  • Note: Supplementary data for this article are available at Molecular Cancer Research Online (http://mcr.aacrjournals.org/).

Abstract

Malignant gliomas are highly invasive tumors with an almost invariably rapid and lethal outcome. Surgery and chemoradiotherapy fail to remove resistant tumor cells that disperse within normal tissue, which are a major cause for disease progression and therapy failure. Infiltration of the neural parenchyma is a distinctive property of malignant gliomas compared with other solid tumors. Thus, glioma cells are thought to produce unique molecular changes that remodel the neural extracellular matrix and form a microenvironment permissive for their motility. Here, we describe the unique expression and proinvasive role of fibulin-3, a mesenchymal matrix protein specifically upregulated in gliomas. Fibulin-3 is downregulated in peripheral tumors and is thought to inhibit tumor growth. However, we found fibulin-3 highly upregulated in gliomas and cultured glioma cells, although the protein was undetectable in normal brain or cultured astrocytes. Overexpression and knockdown experiments revealed that fibulin-3 did not seem to affect glioma cell morphology or proliferation, but enhanced substrate-specific cell adhesion and promoted cell motility and dispersion in organotypic cultures. Moreover, orthotopic implantation of fibulin-3–overexpressing glioma cells resulted in diffuse tumors with increased volume and rostrocaudal extension compared with controls. Tumors and cultured cells overexpressing fibulin-3 also showed elevated expression and activity of matrix metalloproteases, such as MMP-2/MMP-9 and ADAMTS-5. Taken together, our results suggest that fibulin-3 has a unique expression and protumoral role in gliomas, and could be a potential target against tumor progression. Strategies against this glioma-specific matrix component could disrupt invasive mechanisms and restrict the dissemination of these tumors. (Mol Cancer Res 2009;7(11):1756–70)

Keywords
  • EFEMP-1
  • fibulin
  • proteoglycans
  • extracellular matrix
  • glioma invasion

Footnotes

  • Grant support: Seed grants from the American Cancer Society, the Dardinger Center Fund for Neuro-Oncology Research, and the Program in Molecular Biology and Cancer Genetics (Ohio State University-Comprehensive Cancer Center; M.S. Viapiano), and the Joel A. Gringras fellowship from the American Brain Tumor Association (B. Hu).

  • The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

  • Note: Supplementary data for this article are available at Molecular Cancer Research Online (http://mcr.aacrjournals.org/).

    • Received May 20, 2009.
    • Revision received August 4, 2009.
    • Accepted August 24, 2009.
  • © 2009 American Association for Cancer Research.
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This OnlineFirst version was published on November 3, 2009
doi: 10.1158/1541-7786.MCR-09-0207

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Fibulin-3 Is Uniquely Upregulated in Malignant Gliomas and Promotes Tumor Cell Motility and Invasion
Bin Hu, Keerthi K. Thirtamara-Rajamani, Hosung Sim and Mariano S. Viapiano
Mol Cancer Res November 3 2009 DOI: 10.1158/1541-7786.MCR-09-0207

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Fibulin-3 Is Uniquely Upregulated in Malignant Gliomas and Promotes Tumor Cell Motility and Invasion
Bin Hu, Keerthi K. Thirtamara-Rajamani, Hosung Sim and Mariano S. Viapiano
Mol Cancer Res November 3 2009 DOI: 10.1158/1541-7786.MCR-09-0207
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Molecular Cancer Research
eISSN: 1557-3125
ISSN: 1541-7786

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