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Dasatinib Stimulates Its Own Mechanism of Resistance by Activating a CRTC3/MITF/Bcl-2 Pathway in Melanoma with Mutant or Amplified c-Kit
Malak Sabbah, Mohammad Krayem, Ahmad Najem, François Sales, Wilson Miller, Sonia del Rincon, Ahmad Awada, Ghanem E. Ghanem, Fabrice Journe

Molecular Cancer Research Mar 2021, DOI: 10.1158/1541-7786.MCR-20-1040
RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation
Matthew S. Crowe, Tatiana Zavorotinskaya, Charles F. Voliva, Matthew D. Shirley, Yanqun Wang, David A. Ruddy, Daniel P. Rakiec, Jeffery A. Engelman, Darrin D. Stuart, Alyson K. Freeman

Molecular Cancer Research Mar 2021, DOI: 10.1158/1541-7786.MCR-20-1022
Aberrant Claudin-6–Adhesion Signaling Promotes Endometrial Cancer Progression via Estrogen Receptor α
Manabu Kojima, Kotaro Sugimoto, Makoto Kobayashi, Naoki Ichikawa-Tomikawa, Korehito Kashiwagi, Takafumi Watanabe, Shu Soeda, Keiya Fujimori, Hideki Chiba

Molecular Cancer Research Mar 2021, DOI: 10.1158/1541-7786.MCR-20-0835
Identification and Characterization of Cancer Cells That Initiate Metastases to the Brain and Other Organs
Anna. S. Berghoff, Yunxiang Liao, Matthia A. Karreman, Ayseguel Ilhan-Mutlu, Katharina Gunkel, Martin R. Sprick, Christian Eisen, Tobias Kessler, Matthias Osswald, Susanne Wünsche, Manuel Feinauer, Brunhilde Gril, Frederic Marmé, Laura L. Michel, Zuszanna Bago-Horvath, Felix Sahm, Natalia Becker, Michael O. Breckwoldt, Gergely Solecki, Miriam Gömmel, Lulu Huang, Petra Rübmann, Carina M. Thome, Miriam Ratliff, Andreas Trumpp, Patricia S. Steeg, Matthias Preusser, Wolfgang Wick, Frank Winkler

Molecular Cancer Research Apr 2021, 19 (4) 688-701; DOI: 10.1158/1541-7786.MCR-20-0863
Paracrine Placental Growth Factor Signaling in Response to Ionizing Radiation Is p53-Dependent and Contributes to Radioresistance
Tamara Kazimova, Fabienne Tschanz, Ashish Sharma, Irma Telarovic, Marco Wachtel, Gloria Pedot, Beat Schäfer, Martin Pruschy

Molecular Cancer Research Feb 2021, DOI: 10.1158/1541-7786.MCR-20-0403
AXL Inhibition Induces DNA Damage and Replication Stress in Non–Small Cell Lung Cancer Cells and Promotes Sensitivity to ATR Inhibitors
Kavya Ramkumar, C. Allison Stewart, Kasey R. Cargill, Carminia M. Della Corte, Qi Wang, Li Shen, Lixia Diao, Robert J. Cardnell, David H. Peng, B. Leticia Rodriguez, You-Hong Fan, John V. Heymach, Jing Wang, Carl M. Gay, Don L. Gibbons, Lauren A. Byers

Molecular Cancer Research Mar 2021, 19 (3) 485-497; DOI: 10.1158/1541-7786.MCR-20-0414
Silencing of SmgGDS, a Novel mTORC1 Inducer That Binds to RHEBs, Inhibits Malignant Mesothelioma Cell Proliferation
Tatsuhiro Sato, Satomi Mukai, Haruna Ikeda, Emi Mishiro-Sato, Ken Akao, Toshiyuki Kobayashi, Okio Hino, Wataru Shimono, Yoshio Shibagaki, Seisuke Hattori, Yoshitaka Sekido

Molecular Cancer Research Feb 2021, DOI: 10.1158/1541-7786.MCR-20-0637
Preclinical Evaluation of Gilteritinib on NPM1-ALK–Driven Anaplastic Large Cell Lymphoma Cells
Sudhakiranmayi Kuravi, Janice Cheng, Gabrielle Fangman, Kishore Polireddy, Sophia McCormick, Tara L. Lin, Anurag K. Singh, Sunil Abhyankar, Siddhartha Ganguly, Danny R. Welch, Roy A. Jensen, Joseph P. McGuirk, Ramesh Balusu

Molecular Cancer Research Jan 2021, DOI: 10.1158/1541-7786.MCR-20-0738
Breast Tumor Kinase (Brk/PTK6) Mediates Advanced Cancer Phenotypes via SH2-Domain Dependent Activation of RhoA and Aryl Hydrocarbon Receptor (AhR) Signaling
Amy R. Dwyer, Carlos Perez Kerkvliet, Raisa I. Krutilina, Hilaire C. Playa, Deanna N. Parke, Warner A. Thomas, Branden A. Smeester, Branden S. Moriarity, Tiffany N. Seagroves, Carol A. Lange

Molecular Cancer Research Feb 2021, 19 (2) 329-345; DOI: 10.1158/1541-7786.MCR-20-0295
SHOC2 Is a Critical Modulator of Sensitivity to EGFR–TKIs in Non–Small Cell Lung Cancer Cells
Hideki Terai, Junko Hamamoto, Katsura Emoto, Takeshi Masuda, Tadashi Manabe, Satoshi Kuronuma, Keigo Kobayashi, Keita Masuzawa, Shinnosuke Ikemura, Sohei Nakayama, Ichiro Kawada, Yusuke Suzuki, Osamu Takeuchi, Yukio Suzuki, Sumio Ohtsuki, Hiroyuki Yasuda, Kenzo Soejima, Koichi Fukunaga

Molecular Cancer Research Feb 2021, 19 (2) 317-328; DOI: 10.1158/1541-7786.MCR-20-0664

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