Skip to main content
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

AACR logo

  • Register
  • Log in
  • My Cart
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Rapid Impact Archive
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • Metabolism Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Spotlight on Genomic Analysis of Rare and Understudied Cancers
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in
  • My Cart

Search

  • Advanced search
Molecular Cancer Research
Molecular Cancer Research
  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Rapid Impact Archive
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • Metabolism Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Spotlight on Genomic Analysis of Rare and Understudied Cancers
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

Highlights

Highlights of This Issue

DOI:  Published December 2011
  • Article
  • Info & Metrics
  • PDF
Loading

Twist1 Cooperates with Snail1 to Maintain EMT

Tran et al. Page 1644

Epithelial-mesenchymal transition (EMT) has been implicated in the initial stages of metastasis. What remains unclear, however, is how it is maintained in late metastatic cells and whether it also regulates the subsequent dormant state of micrometastases. Tran and colleagues detail a mechanistic link between EMT and cancer dormancy in which Snail1 and Twist1, two key EMT inducers, cooperate with each other to initiate and maintain EMT, respectively, and in so doing Twist1 contributes directly to the cancer dormancy program. Therefore, Twist1 represents a potential therapeutic target to manipulate tumor dormancy for clinical benefits.

A Role for Trop2 Loss in Carcinogenesis

Wang et al. Page 1686

The transmembrane protein Trop2 has been reported to be overexpressed in carcinomas, but its function remains largely unknown. In an effort to elucidate its role in tumorigenesis, Wang and colleagues generated Trop2−/− animals, which lack an obvious tumor phenotype. However, when mated into an Arf-null background and exposed to carcinogens, Trop2−/− mice develop tumors with both squamous and spindle cell histology. Accordingly, immortalized cells from Trop2−/− Arf−/− mice show hyperactivation of MAPK and Src pathways. Additionally, poorly differentiated head and neck cancers exhibit low Trop2 levels. These results identify a tumor suppressor role and highlight unexpected signaling properties for this protein.

DNA-PK Blockade and Radiation-Induced Senescence

Azad et al. Page 1696

In this study, Azad and colleagues present the first report of DNA-dependent protein kinase (DNA-PK) blockade leading to accelerated senescence in irradiated human cancer cells. The study shows that DNAPK inhibition modulates repair of therapeutically induced DNA doublestrand breaks and thus promotes p53-dependent accelerated senescence in irradiated cells. Significantly, this report notes the lack of clinical trials using novel pharmacological inhibitors of DNA-PK in conjunction with ionizing radiation. Thus, these data provide a sound rationale for both preclinical and clinical evaluation of novel DNA-PK inhibitors in combination with ionizing radiation and other anticancer agents that induce doublestrand breaks or inhibit double-strand break repair.

YB-1 Transactivates Clusterin during Treatment Stress

Shiota et al. Page 1755

Many strategies used to kill cancer cells induce stress-responses that inhibit treatment-induced cell death and promote emergence of a treatment resistant phenotype. Whereas both Y-box binding protein-1 (YB-1) and clusterin are known to confer taxane resistance in cancer, their mechanistic interrelationships are undefined. Shiota and colleagues found that many varied anticancer therapeutic agents including taxanes induce endoplasmic reticulum stress with activation of YB-1. YB-1 was shown to be a critical regulator of stress-induced clusterin transcription and expression, and clusterin was shown to play a dominant downstream mediator of YB-1 in stressinduced cytoprotection and paclitaxel resistance in prostate cancer cells.

  • ©2011 American Association for Cancer Research.
PreviousNext
Back to top
Molecular Cancer Research: 9 (12)
December 2011
Volume 9, Issue 12
  • Table of Contents
  • About the Cover

Sign up for alerts

View this article with LENS

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Molecular Cancer Research article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Highlights of This Issue
(Your Name) has forwarded a page to you from Molecular Cancer Research
(Your Name) thought you would be interested in this article in Molecular Cancer Research.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Highlights of This Issue
Mol Cancer Res December 1 2011 (9) (12) 1571;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Highlights of This Issue
Mol Cancer Res December 1 2011 (9) (12) 1571;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Twist1 Cooperates with Snail1 to Maintain EMT
    • A Role for Trop2 Loss in Carcinogenesis
    • DNA-PK Blockade and Radiation-Induced Senescence
    • YB-1 Transactivates Clusterin during Treatment Stress
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

  • Selected Articles from This Issue
  • Selected Articles from This Issue
  • Selected Articles from This Issue
Show more Highlights
  • Home
  • Alerts
  • Feedback
  • Privacy Policy
Facebook  Twitter  LinkedIn  YouTube  RSS

Articles

  • Online First
  • Current Issue
  • Past Issues
  • Rapid Impact Archive
  • Meeting Abstracts

Information for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians

About MCR

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2021 by the American Association for Cancer Research.

Molecular Cancer Research
eISSN: 1557-3125
ISSN: 1541-7786

Advertisement