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Molecular Cancer Research
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Roles of Fibroblast Growth Factor Receptors in Carcinogenesis

Ellen Margrethe Haugsten, Antoni Wiedlocha, Sjur Olsnes and Jørgen Wesche
Ellen Margrethe Haugsten
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Antoni Wiedlocha
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Sjur Olsnes
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Jørgen Wesche
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DOI: 10.1158/1541-7786.MCR-10-0168 Published November 2010
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Abstract

The fibroblast growth factor receptors (FGFR) play essential roles both during development and in the adult. Upon ligand binding, FGFRs induce intracellular signaling networks that tightly regulate key biological processes, such as cell proliferation, survival, migration, and differentiation. Deregulation of FGFR signaling can thus alter tissue homeostasis and has been associated with several developmental syndromes as well as with many types of cancer. In human cancer, FGFRs have been found to be deregulated by multiple mechanisms, including aberrant expression, mutations, chromosomal rearrangements, and amplifications. In this review, we will give an overview of the main FGFR alterations described in human cancer to date and discuss their contribution to cancer progression. Mol Cancer Res; 8(11); 1439–52. ©2010 AACR.

  • Received April 19, 2010.
  • Revision received September 17, 2010.
  • Accepted October 1, 2010.
  • ©2010 American Association for Cancer Research.
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Molecular Cancer Research: 8 (11)
November 2010
Volume 8, Issue 11
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Roles of Fibroblast Growth Factor Receptors in Carcinogenesis
Ellen Margrethe Haugsten, Antoni Wiedlocha, Sjur Olsnes and Jørgen Wesche
Mol Cancer Res November 1 2010 (8) (11) 1439-1452; DOI: 10.1158/1541-7786.MCR-10-0168

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Roles of Fibroblast Growth Factor Receptors in Carcinogenesis
Ellen Margrethe Haugsten, Antoni Wiedlocha, Sjur Olsnes and Jørgen Wesche
Mol Cancer Res November 1 2010 (8) (11) 1439-1452; DOI: 10.1158/1541-7786.MCR-10-0168
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Molecular Cancer Research
eISSN: 1557-3125
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