TUNEL analysis showing increased cell death in intestinal polyps from Apc^Min/+ c-myc^+/- mice when compared to polyps isolated from Apc^Min/+ c-myc^+/+ mice. Representational field of an intestinal polyp from an Apc^Min/+ c-myc^+/- mouse following TUNEL staining. Deparaffinized tissue sections were permeabilized and then incubated with TUNEL reaction mixture containing TdT and fluorescein-dUTP, rinsed in PBS, mounted and analyzed using a Leica LSM 510 laser scanning microscope. ImagePro Plus software was used to quantify the number of TUNEL positive nuclei. For details, see the article by Yekkala and Baudino 1296.