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Molecular Cancer Research
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Cell Fate Decisions

The Heme-Regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics

Kaitlyn H. Smith, Amit Budhraja, John Lynch, Kathryn Roberts, John C. Panetta, Jon P. Connelly, Meghan E. Turnis, Shondra M. Pruett-Miller, John D. Schuetz, Charles G. Mullighan and Joseph T. Opferman
Kaitlyn H. Smith
1Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
2Integrated Program in Biomedical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee.
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Amit Budhraja
1Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
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John Lynch
3Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee.
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Kathryn Roberts
4Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.
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John C. Panetta
3Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee.
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Jon P. Connelly
1Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
5Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, Tennessee.
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Meghan E. Turnis
1Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
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Shondra M. Pruett-Miller
1Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
5Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, Tennessee.
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John D. Schuetz
3Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee.
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Charles G. Mullighan
4Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.
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Joseph T. Opferman
1Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
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  • For correspondence: Joseph.Opferman@stjude.org
DOI: 10.1158/1541-7786.MCR-20-0586 Published April 2021
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Article Information

Volume 19, Issue 4, pp. 636-650

DOI 
https://doi.org/10.1158/1541-7786.MCR-20-0586
PubMed 
33288732

Published By 
American Association for Cancer Research
Print ISSN 
1541-7786
Online ISSN 
1557-3125
History 
  • Received July 1, 2020
  • Revision received October 28, 2020
  • Accepted December 2, 2020
  • Published first December 7, 2020.

Article Versions

  • Previous version (December 7, 2020 - 05:41).
  • Previous version (January 14, 2021 - 05:40).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2020 American Association for Cancer Research.

Author Information

  1. Kaitlyn H. Smith1,2,#,
  2. Amit Budhraja1,#,
  3. John Lynch3,
  4. Kathryn Roberts4,
  5. John C. Panetta3,
  6. Jon P. Connelly1,5,
  7. Meghan E. Turnis1,
  8. Shondra M. Pruett-Miller1,5,
  9. John D. Schuetz3,
  10. Charles G. Mullighan4, and
  11. Joseph T. Opferman1,*
  1. 1Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
  2. 2Integrated Program in Biomedical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee.
  3. 3Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee.
  4. 4Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.
  5. 5Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, Tennessee.
  1. ↵*Corresponding Author:
    Joseph T. Opferman, St. Jude Children's Research Hospital, 262 Danny Thomas Place, D-4007C, Memphis, TN 38105. Phone: 901-595-5524; Fax: 901-525-8025; E-mail: Joseph.Opferman{at}stjude.org
  1. ↵#K.H. Smith and A. Budhraja contributed equally to this article.

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Molecular Cancer Research: 19 (4)
April 2021
Volume 19, Issue 4
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The Heme-Regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics
Kaitlyn H. Smith, Amit Budhraja, John Lynch, Kathryn Roberts, John C. Panetta, Jon P. Connelly, Meghan E. Turnis, Shondra M. Pruett-Miller, John D. Schuetz, Charles G. Mullighan and Joseph T. Opferman
Mol Cancer Res April 1 2021 (19) (4) 636-650; DOI: 10.1158/1541-7786.MCR-20-0586

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The Heme-Regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics
Kaitlyn H. Smith, Amit Budhraja, John Lynch, Kathryn Roberts, John C. Panetta, Jon P. Connelly, Meghan E. Turnis, Shondra M. Pruett-Miller, John D. Schuetz, Charles G. Mullighan and Joseph T. Opferman
Mol Cancer Res April 1 2021 (19) (4) 636-650; DOI: 10.1158/1541-7786.MCR-20-0586
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