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Molecular Cancer Research
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AraC-FdUMP[10] Is a Next-Generation Fluoropyrimidine with Potent Antitumor Activity in PDAC and Synergy with PARG Inhibition

Alex O. Haber, Aditi Jain, Chinnadurai Mani, Avinoam Nevler, Lebaron C. Agostini, Talia Golan, Komaraiah Palle, Charles J. Yeo, William H. Gmeiner and Jonathan R. Brody
Alex O. Haber
1The Jefferson Pancreas, Biliary and Related Cancer Center, Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania.
2Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.
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Aditi Jain
1The Jefferson Pancreas, Biliary and Related Cancer Center, Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania.
2Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.
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Chinnadurai Mani
3Texas Tech University Health Sciences Center, Lubbock, Texas.
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Avinoam Nevler
1The Jefferson Pancreas, Biliary and Related Cancer Center, Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania.
2Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.
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  • ORCID record for Avinoam Nevler
Lebaron C. Agostini
1The Jefferson Pancreas, Biliary and Related Cancer Center, Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania.
2Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.
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  • ORCID record for Lebaron C. Agostini
Talia Golan
4Oncology Institute, Chaim Sheba Medical Center, Tel Aviv, Israel.
5Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
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Komaraiah Palle
3Texas Tech University Health Sciences Center, Lubbock, Texas.
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Charles J. Yeo
1The Jefferson Pancreas, Biliary and Related Cancer Center, Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania.
2Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.
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William H. Gmeiner
6Deparment of Cancer Biology, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
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  • For correspondence: brodyj@ohsu.edu bgmeiner@wakehealth.edu
Jonathan R. Brody
7Department of Surgery and Cell, Developmental and Cancer Biology, Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.
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  • For correspondence: brodyj@ohsu.edu bgmeiner@wakehealth.edu
DOI: 10.1158/1541-7786.MCR-20-0985 Published April 2021
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Article Information

Volume 19, Issue 4, pp. 565-572

DOI 
https://doi.org/10.1158/1541-7786.MCR-20-0985
PubMed 
33593942

Published By 
American Association for Cancer Research
Print ISSN 
1541-7786
Online ISSN 
1557-3125
History 
  • Received November 17, 2020
  • Revision received December 16, 2020
  • Accepted February 10, 2021
  • Published first February 16, 2021.

Article Versions

  • Previous version (February 16, 2021 - 05:51).
  • Previous version (March 4, 2021 - 06:43).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2021 American Association for Cancer Research.

Author Information

  1. Alex O. Haber1,2,
  2. Aditi Jain1,2,
  3. Chinnadurai Mani3,
  4. Avinoam Nevler1,2,
  5. Lebaron C. Agostini1,2,
  6. Talia Golan4,5,
  7. Komaraiah Palle3,
  8. Charles J. Yeo1,2,
  9. William H. Gmeiner6,#,*, and
  10. Jonathan R. Brody7,#,*
  1. 1The Jefferson Pancreas, Biliary and Related Cancer Center, Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania.
  2. 2Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.
  3. 3Texas Tech University Health Sciences Center, Lubbock, Texas.
  4. 4Oncology Institute, Chaim Sheba Medical Center, Tel Aviv, Israel.
  5. 5Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  6. 6Deparment of Cancer Biology, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
  7. 7Department of Surgery and Cell, Developmental and Cancer Biology, Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.
  1. ↵*Corresponding Authors:
    Jonathan R. Brody, Department of Surgery Oregon Health & Science University, Portland, OR 97239. E-mail: brodyj{at}ohsu.edu; and William H. Gmeiner, bgmeiner{at}wakehealth.edu
  1. ↵#W.H. Gmeiner and J.R. Brody contributed equally to this article.

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Molecular Cancer Research: 19 (4)
April 2021
Volume 19, Issue 4
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AraC-FdUMP[10] Is a Next-Generation Fluoropyrimidine with Potent Antitumor Activity in PDAC and Synergy with PARG Inhibition
Alex O. Haber, Aditi Jain, Chinnadurai Mani, Avinoam Nevler, Lebaron C. Agostini, Talia Golan, Komaraiah Palle, Charles J. Yeo, William H. Gmeiner and Jonathan R. Brody
Mol Cancer Res April 1 2021 (19) (4) 565-572; DOI: 10.1158/1541-7786.MCR-20-0985

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AraC-FdUMP[10] Is a Next-Generation Fluoropyrimidine with Potent Antitumor Activity in PDAC and Synergy with PARG Inhibition
Alex O. Haber, Aditi Jain, Chinnadurai Mani, Avinoam Nevler, Lebaron C. Agostini, Talia Golan, Komaraiah Palle, Charles J. Yeo, William H. Gmeiner and Jonathan R. Brody
Mol Cancer Res April 1 2021 (19) (4) 565-572; DOI: 10.1158/1541-7786.MCR-20-0985
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