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Molecular Cancer Research
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Cancer Genes and Networks

N-Acetyl-L-cysteine Promotes Ex Vivo Growth and Expansion of Single Circulating Tumor Cells by Mitigating Cellular Stress Responses

Teng Teng, Mohamed Kamal, Oihana Iriondo, Yonatan Amzaleg, Chunqiao Luo, Amal Thomas, Grace Lee, Ching-Ju Hsu, John D. Nguyen, Irene Kang, James Hicks, Andrew Smith, Richard Sposto and Min Yu
Teng Teng
1Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
2USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California.
3The Second XiangYa Hospital of Central South University, XiangYa School of Medicine, Central South University, ChangSha, HuNan, China.
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Mohamed Kamal
1Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
2USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California.
4Department of Zoology, Faculty of Science, University of Benha, Benha, Egypt.
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  • ORCID record for Mohamed Kamal
Oihana Iriondo
1Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
2USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California.
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  • ORCID record for Oihana Iriondo
Yonatan Amzaleg
1Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
2USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California.
5Center for Craniofacial Molecular Biology, Ostrow School of Dentistry of the University of Southern California, Los Angeles, California.
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Chunqiao Luo
6Biostatistics Core, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
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Amal Thomas
7Department of Molecular and Computational Biology, USC David and Dana Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California.
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  • ORCID record for Amal Thomas
Grace Lee
1Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
2USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California.
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Ching-Ju Hsu
8Bridge Institute, USC David and Dana Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California.
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John D. Nguyen
1Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
2USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California.
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Irene Kang
2USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California.
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James Hicks
8Bridge Institute, USC David and Dana Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California.
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Andrew Smith
7Department of Molecular and Computational Biology, USC David and Dana Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California.
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Richard Sposto
6Biostatistics Core, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
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Min Yu
1Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
2USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California.
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  • For correspondence: minyu@med.usc.edu
DOI: 10.1158/1541-7786.MCR-20-0482 Published March 2021
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Article Information

Volume 19, Issue 3, pp. 441-450

DOI 
https://doi.org/10.1158/1541-7786.MCR-20-0482
PubMed 
33303691

Published By 
American Association for Cancer Research
Print ISSN 
1541-7786
Online ISSN 
1557-3125
History 
  • Received May 26, 2020
  • Revision received September 11, 2020
  • Accepted December 7, 2020
  • Published first December 10, 2020.

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  • Previous version (December 10, 2020 - 05:43).
  • Previous version (January 14, 2021 - 05:40).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2020 American Association for Cancer Research.

Author Information

  1. Teng Teng1,2,3,#,
  2. Mohamed Kamal1,2,4,#,
  3. Oihana Iriondo1,2,
  4. Yonatan Amzaleg1,2,5,
  5. Chunqiao Luo6,
  6. Amal Thomas7,
  7. Grace Lee1,2,
  8. Ching-Ju Hsu8,
  9. John D. Nguyen1,2,
  10. Irene Kang2,
  11. James Hicks8,
  12. Andrew Smith7,
  13. Richard Sposto6, and
  14. Min Yu1,2,*
  1. 1Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
  2. 2USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California.
  3. 3The Second XiangYa Hospital of Central South University, XiangYa School of Medicine, Central South University, ChangSha, HuNan, China.
  4. 4Department of Zoology, Faculty of Science, University of Benha, Benha, Egypt.
  5. 5Center for Craniofacial Molecular Biology, Ostrow School of Dentistry of the University of Southern California, Los Angeles, California.
  6. 6Biostatistics Core, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
  7. 7Department of Molecular and Computational Biology, USC David and Dana Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California.
  8. 8Bridge Institute, USC David and Dana Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California.
  1. ↵*Corresponding Author:
    Min Yu, University of Southern California, 1450 Biggy Street, NRT 3507, Los Angeles, CA 90033. Phone: 323-442-7943; E-mail: minyu{at}med.usc.edu
  1. ↵#T. Teng and M. Kamal contributed equally to this article.

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Molecular Cancer Research: 19 (3)
March 2021
Volume 19, Issue 3
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N-Acetyl-L-cysteine Promotes Ex Vivo Growth and Expansion of Single Circulating Tumor Cells by Mitigating Cellular Stress Responses
Teng Teng, Mohamed Kamal, Oihana Iriondo, Yonatan Amzaleg, Chunqiao Luo, Amal Thomas, Grace Lee, Ching-Ju Hsu, John D. Nguyen, Irene Kang, James Hicks, Andrew Smith, Richard Sposto and Min Yu
Mol Cancer Res March 1 2021 (19) (3) 441-450; DOI: 10.1158/1541-7786.MCR-20-0482

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N-Acetyl-L-cysteine Promotes Ex Vivo Growth and Expansion of Single Circulating Tumor Cells by Mitigating Cellular Stress Responses
Teng Teng, Mohamed Kamal, Oihana Iriondo, Yonatan Amzaleg, Chunqiao Luo, Amal Thomas, Grace Lee, Ching-Ju Hsu, John D. Nguyen, Irene Kang, James Hicks, Andrew Smith, Richard Sposto and Min Yu
Mol Cancer Res March 1 2021 (19) (3) 441-450; DOI: 10.1158/1541-7786.MCR-20-0482
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