Transcriptomic Analysis of Diffuse Intrinsic Pontine Glioma (DIPG) Identifies a Targetable ALDH-Positive Subset of Highly Tumorigenic Cancer Stem-like Cells

Rachel K. Surowiec; Sarah F. Ferris; April Apfelbaum; Carlos Espinoza; Ranjit K. Mehta; Karamoja Monchamp; Veerin R. Sirihorachai; Karan Bedi; Mats Ljungman; Stefanie Galban

doi:10.1158/1541-7786.MCR-20-0464

Cancer Genes and Networks

Transcriptomic Analysis of Diffuse Intrinsic Pontine Glioma (DIPG) Identifies a Targetable ALDH-Positive Subset of Highly Tumorigenic Cancer Stem-like Cells

Rachel K. Surowiec, Sarah F. Ferris, April Apfelbaum, Carlos Espinoza, Ranjit K. Mehta, Karamoja Monchamp, Veerin R. Sirihorachai, Karan Bedi, Mats Ljungman and Stefanie Galban

Rachel K. Surowiec

1Center for Molecular Imaging, The University of Michigan Medical School, Ann Arbor, Michigan.

2Department of Radiology, The University of Michigan Medical School, Ann Arbor, Michigan.

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Sarah F. Ferris

1Center for Molecular Imaging, The University of Michigan Medical School, Ann Arbor, Michigan.

2Department of Radiology, The University of Michigan Medical School, Ann Arbor, Michigan.

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April Apfelbaum

1Center for Molecular Imaging, The University of Michigan Medical School, Ann Arbor, Michigan.

2Department of Radiology, The University of Michigan Medical School, Ann Arbor, Michigan.

3Cancer Biology Graduate Program, The University of Michigan Medical School, Ann Arbor, Michigan.

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Carlos Espinoza

1Center for Molecular Imaging, The University of Michigan Medical School, Ann Arbor, Michigan.

2Department of Radiology, The University of Michigan Medical School, Ann Arbor, Michigan.

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Ranjit K. Mehta

1Center for Molecular Imaging, The University of Michigan Medical School, Ann Arbor, Michigan.

2Department of Radiology, The University of Michigan Medical School, Ann Arbor, Michigan.

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Karamoja Monchamp

1Center for Molecular Imaging, The University of Michigan Medical School, Ann Arbor, Michigan.

2Department of Radiology, The University of Michigan Medical School, Ann Arbor, Michigan.

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Veerin R. Sirihorachai

3Cancer Biology Graduate Program, The University of Michigan Medical School, Ann Arbor, Michigan.

4Rogel Cancer Center, The University of Michigan Medical School, Ann Arbor, Michigan.

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Karan Bedi

3Cancer Biology Graduate Program, The University of Michigan Medical School, Ann Arbor, Michigan.

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Mats Ljungman

4Rogel Cancer Center, The University of Michigan Medical School, Ann Arbor, Michigan.

5Department of Radiation Oncology, The University of Michigan Medical School, Ann Arbor, Michigan.

6Department of Environmental Health Sciences, The University of Michigan Medical School, Ann Arbor, Michigan.

7Center for RNA Biomedicine, The University of Michigan Medical School, Ann Arbor, Michigan.

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Stefanie Galban

1Center for Molecular Imaging, The University of Michigan Medical School, Ann Arbor, Michigan.

2Department of Radiology, The University of Michigan Medical School, Ann Arbor, Michigan.

4Rogel Cancer Center, The University of Michigan Medical School, Ann Arbor, Michigan.

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For correspondence: sgalban@umich.edu

DOI: 10.1158/1541-7786.MCR-20-0464 Published February 2021

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February 2021
Volume 19, Issue 2

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Transcriptomic Analysis of Diffuse Intrinsic Pontine Glioma (DIPG) Identifies a Targetable ALDH-Positive Subset of Highly Tumorigenic Cancer Stem-like Cells

Rachel K. Surowiec, Sarah F. Ferris, April Apfelbaum, Carlos Espinoza, Ranjit K. Mehta, Karamoja Monchamp, Veerin R. Sirihorachai, Karan Bedi, Mats Ljungman and Stefanie Galban

Mol Cancer Res February 1 2021 (19) (2) 223-239; DOI: 10.1158/1541-7786.MCR-20-0464

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Transcriptomic Analysis of Diffuse Intrinsic Pontine Glioma (DIPG) Identifies a Targetable ALDH-Positive Subset of Highly Tumorigenic Cancer Stem-like Cells

Rachel K. Surowiec, Sarah F. Ferris, April Apfelbaum, Carlos Espinoza, Ranjit K. Mehta, Karamoja Monchamp, Veerin R. Sirihorachai, Karan Bedi, Mats Ljungman and Stefanie Galban

Mol Cancer Res February 1 2021 (19) (2) 223-239; DOI: 10.1158/1541-7786.MCR-20-0464

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