Molecular Cancer Research: 19 (2)

Highlights

Highlights

Selected Articles from This Issue

Mol Cancer Res February 1 2021 19 (2) 165-165;

Reviews

Reviews

Cellular Functions of HPV16 E5 Oncoprotein during Oncogenic Transformation

Lourdes Gutierrez-Xicotencatl, Adolfo Pedroza-Saavedra, Lilia Chihu-Amparan, Azucena Salazar-Piña, Minerva Maldonado-Gama and Fernando Esquivel-Guadarrama

Mol Cancer Res February 1 2021 19 (2) 167-179; DOI:10.1158/1541-7786.MCR-20-0491
Reviews

The Paradoxical Roles of Orphan Nuclear Receptor 4A (NR4A) in Cancer

Stephen Safe and Keshav Karki

Mol Cancer Res February 1 2021 19 (2) 180-191; DOI:10.1158/1541-7786.MCR-20-0707
Reviews

Exploiting Replication Stress as a Novel Therapeutic Intervention

Jeffrey C. Martin, Tamara J. Hoegel, Miranda L. Lynch, Anna Woloszynska, Thomas Melendy and Joyce E. Ohm

Mol Cancer Res February 1 2021 19 (2) 192-206; DOI:10.1158/1541-7786.MCR-20-0651

Rapid Impact

Rapid Impact

Combined Targeting of PARG and Wee1 Causes Decreased Cell Survival and DNA Damage in an S-Phase–Dependent Manner

Lebaron C. Agostini, Aditi Jain, Alison Shupp, Avinoam Nevler, Grace McCarthy, Karen M. Bussard, Charles J. Yeo and Jonathan R. Brody

Mol Cancer Res February 1 2021 19 (2) 207-214; DOI:10.1158/1541-7786.MCR-20-0708

Cancer Genes and Networks

Cancer Genes and Networks

Dual Screen for Efficacy and Toxicity Identifies HDAC Inhibitor with Distinctive Activity Spectrum for BAP1-Mutant Uveal Melanoma

Jeffim N. Kuznetsoff, Dawn A. Owens, Andy Lopez, Daniel A. Rodriguez, Nancy T. Chee, Stefan Kurtenbach, Daniel Bilbao, Evan R. Roberts, Claude-Henry Volmar, Claes Wahlestedt, Shaun P. Brothers and J. William Harbour

Mol Cancer Res February 1 2021 19 (2) 215-222; DOI:10.1158/1541-7786.MCR-20-0434
Cancer Genes and Networks

Transcriptomic Analysis of Diffuse Intrinsic Pontine Glioma (DIPG) Identifies a Targetable ALDH-Positive Subset of Highly Tumorigenic Cancer Stem-like Cells

Rachel K. Surowiec, Sarah F. Ferris, April Apfelbaum, Carlos Espinoza, Ranjit K. Mehta, Karamoja Monchamp, Veerin R. Sirihorachai, Karan Bedi, Mats Ljungman and Stefanie Galban

Mol Cancer Res February 1 2021 19 (2) 223-239; DOI:10.1158/1541-7786.MCR-20-0464
Cancer Genes and Networks

Palmitate-Induced IRE1–XBP1–ZEB Signaling Represses Desmoplakin Expression and Promotes Cancer Cell Migration

Aritro Nath, Amrita Oak, Kevin Y. Chen, Irene Li, R. Chauncey Splichal, Jason Portis, Sean Foster, S. Patrick Walton and Christina Chan

Mol Cancer Res February 1 2021 19 (2) 240-248; DOI:10.1158/1541-7786.MCR-19-0480
Cancer Genes and Networks

Aggressive B-cell Lymphoma with MYC/TP53 Dual Alterations Displays Distinct Clinicopathobiological Features and Response to Novel Targeted Agents

Manman Deng, Zijun Y. Xu-Monette, Lan V. Pham, Xudong Wang, Alexandar Tzankov, Xiaosheng Fang, Feng Zhu, Carlo Visco, Govind Bhagat, Karen Dybkaer, April Chiu, Wayne Tam, Youli Zu, Eric D. Hsi, Hua You, Jooryung Huh, Maurilio Ponzoni, Andrés J.M. Ferreri, Michael B. Møller, Benjamin M. Parsons, Fredrick Hagemeister, J. Han van Krieken, Miguel A. Piris, Jane N. Winter, Yong Li, Bing Xu, Phillip Liu and Ken H. Young

Mol Cancer Res February 1 2021 19 (2) 249-260; DOI:10.1158/1541-7786.MCR-20-0466
Cancer Genes and Networks

FBW7 Inhibits Myeloid Differentiation in Acute Myeloid Leukemia via GSK3-Dependent Ubiquitination of PU.1

Mukul Mishra, Gatha Thacker, Akshay Sharma, Anil Kumar Singh, Vishal Upadhyay, Sabyasachi Sanyal, Shailendra Prasad Verma, Anil Kumar Tripathi, Madan Lal Brahma Bhatt and Arun Kumar Trivedi

Mol Cancer Res February 1 2021 19 (2) 261-273; DOI:10.1158/1541-7786.MCR-20-0268

Cell Fate Decisions

Cell Fate Decisions

A Role for the Autophagic Receptor, SQSTM1/p62, in Trafficking NF-κB/RelA to Nucleolar Aggresomes

Ian T. Lobb, Pierre Morin, Kirsty Martin, Hazel C. Thoms, Jimi C. Wills, Xhordi Lleshi, Karl C.F. Olsen, Rory R. Duncan and Lesley A. Stark

Mol Cancer Res February 1 2021 19 (2) 274-287; DOI:10.1158/1541-7786.MCR-20-0336
Cell Fate Decisions

Intraperitoneal Oil Application Causes Local Inflammation with Depletion of Resident Peritoneal Macrophages

Elisenda Alsina-Sanchis, Ronja Mülfarth, Iris Moll, Carolin Mogler, Juan Rodriguez-Vita and Andreas Fischer

Mol Cancer Res February 1 2021 19 (2) 288-300; DOI:10.1158/1541-7786.MCR-20-0650

Genome Maintenance

Genome Maintenance

SLX4IP Promotes Telomere Maintenance in Androgen Receptor–Independent Castration-Resistant Prostate Cancer through ALT-like Telomeric PML Localization

Tawna L. Mangosh, Wisam N. Awadallah, Magdalena M. Grabowska and Derek J. Taylor

Mol Cancer Res February 1 2021 19 (2) 301-316; DOI:10.1158/1541-7786.MCR-20-0314

Signal Transduction and Functional Imaging

Signal Transduction and Functional Imaging

SHOC2 Is a Critical Modulator of Sensitivity to EGFR–TKIs in Non–Small Cell Lung Cancer Cells

Hideki Terai, Junko Hamamoto, Katsura Emoto, Takeshi Masuda, Tadashi Manabe, Satoshi Kuronuma, Keigo Kobayashi, Keita Masuzawa, Shinnosuke Ikemura, Sohei Nakayama, Ichiro Kawada, Yusuke Suzuki, Osamu Takeuchi, Yukio Suzuki, Sumio Ohtsuki, Hiroyuki Yasuda, Kenzo Soejima and Koichi Fukunaga

Mol Cancer Res February 1 2021 19 (2) 317-328; DOI:10.1158/1541-7786.MCR-20-0664
Signal Transduction and Functional Imaging

Breast Tumor Kinase (Brk/PTK6) Mediates Advanced Cancer Phenotypes via SH2-Domain Dependent Activation of RhoA and Aryl Hydrocarbon Receptor (AhR) Signaling

Amy R. Dwyer, Carlos Perez Kerkvliet, Raisa I. Krutilina, Hilaire C. Playa, Deanna N. Parke, Warner A. Thomas, Branden A. Smeester, Branden S. Moriarity, Tiffany N. Seagroves and Carol A. Lange

Mol Cancer Res February 1 2021 19 (2) 329-345; DOI:10.1158/1541-7786.MCR-20-0295

Tumor Microenvironment and Immunobiology

Tumor Microenvironment and Immunobiology

Studying Immunotherapy Resistance in a Melanoma Autologous Humanized Mouse Xenograft

J. Jason Morton, Nathaniel Alzofon, Stephen B. Keysar, Tugs-Saikhan Chimed, Julie Reisinger, Loni Perrenoud, Phuong N. Le, Cera Nieto, Karina Gomez, Bettina Miller, Randi Yeager, Dexiang Gao, Aik-Choon Tan, Hilary Somerset, Theresa Medina, Xiao-Jing Wang, Jing H. Wang, William Robinson, Dennis R. Roop, Rene Gonzalez and Antonio Jimeno

Mol Cancer Res February 1 2021 19 (2) 346-357; DOI:10.1158/1541-7786.MCR-20-0686

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Table of Contents

Highlights

Reviews

Rapid Impact

Cancer Genes and Networks

Cell Fate Decisions

Genome Maintenance

Signal Transduction and Functional Imaging

Tumor Microenvironment and Immunobiology

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