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Molecular Cancer Research
Molecular Cancer Research
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Table of Contents

Highlights

  • Highlights
    Selected Articles from This Issue
    Mol Cancer Res February 1 2021 19 (2) 165-165;

Reviews

  • Reviews
    Cellular Functions of HPV16 E5 Oncoprotein during Oncogenic Transformation
    Lourdes Gutierrez-Xicotencatl, Adolfo Pedroza-Saavedra, Lilia Chihu-Amparan, Azucena Salazar-Piña, Minerva Maldonado-Gama and Fernando Esquivel-Guadarrama
    Mol Cancer Res February 1 2021 19 (2) 167-179; DOI:10.1158/1541-7786.MCR-20-0491

  • Reviews
    The Paradoxical Roles of Orphan Nuclear Receptor 4A (NR4A) in Cancer
    Stephen Safe and Keshav Karki
    Mol Cancer Res February 1 2021 19 (2) 180-191; DOI:10.1158/1541-7786.MCR-20-0707

  • Reviews
    Exploiting Replication Stress as a Novel Therapeutic Intervention
    Jeffrey C. Martin, Tamara J. Hoegel, Miranda L. Lynch, Anna Woloszynska, Thomas Melendy and Joyce E. Ohm
    Mol Cancer Res February 1 2021 19 (2) 192-206; DOI:10.1158/1541-7786.MCR-20-0651

Rapid Impact

  • Combined Targeting of PARG and Wee1 Causes Decreased Cell Survival and DNA Damage in an S-Phase–Dependent Manner
    Rapid Impact
    Combined Targeting of PARG and Wee1 Causes Decreased Cell Survival and DNA Damage in an S-Phase–Dependent Manner
    Lebaron C. Agostini, Aditi Jain, Alison Shupp, Avinoam Nevler, Grace McCarthy, Karen M. Bussard, Charles J. Yeo and Jonathan R. Brody
    Mol Cancer Res February 1 2021 19 (2) 207-214; DOI:10.1158/1541-7786.MCR-20-0708

Cancer Genes and Networks

  • Cancer Genes and Networks
    Dual Screen for Efficacy and Toxicity Identifies HDAC Inhibitor with Distinctive Activity Spectrum for BAP1-Mutant Uveal Melanoma
    Jeffim N. Kuznetsoff, Dawn A. Owens, Andy Lopez, Daniel A. Rodriguez, Nancy T. Chee, Stefan Kurtenbach, Daniel Bilbao, Evan R. Roberts, Claude-Henry Volmar, Claes Wahlestedt, Shaun P. Brothers and J. William Harbour
    Mol Cancer Res February 1 2021 19 (2) 215-222; DOI:10.1158/1541-7786.MCR-20-0434

  • Cancer Genes and Networks
    Transcriptomic Analysis of Diffuse Intrinsic Pontine Glioma (DIPG) Identifies a Targetable ALDH-Positive Subset of Highly Tumorigenic Cancer Stem-like Cells
    Rachel K. Surowiec, Sarah F. Ferris, April Apfelbaum, Carlos Espinoza, Ranjit K. Mehta, Karamoja Monchamp, Veerin R. Sirihorachai, Karan Bedi, Mats Ljungman and Stefanie Galban
    Mol Cancer Res February 1 2021 19 (2) 223-239; DOI:10.1158/1541-7786.MCR-20-0464

  • Cancer Genes and Networks
    Palmitate-Induced IRE1–XBP1–ZEB Signaling Represses Desmoplakin Expression and Promotes Cancer Cell Migration
    Aritro Nath, Amrita Oak, Kevin Y. Chen, Irene Li, R. Chauncey Splichal, Jason Portis, Sean Foster, S. Patrick Walton and Christina Chan
    Mol Cancer Res February 1 2021 19 (2) 240-248; DOI:10.1158/1541-7786.MCR-19-0480

  • Aggressive B-cell Lymphoma with MYC/TP53 Dual Alterations Displays Distinct Clinicopathobiological Features and Response to Novel Targeted Agents
    Cancer Genes and Networks
    Aggressive B-cell Lymphoma with MYC/TP53 Dual Alterations Displays Distinct Clinicopathobiological Features and Response to Novel Targeted Agents
    Manman Deng, Zijun Y. Xu-Monette, Lan V. Pham, Xudong Wang, Alexandar Tzankov, Xiaosheng Fang, Feng Zhu, Carlo Visco, Govind Bhagat, Karen Dybkaer, April Chiu, Wayne Tam, Youli Zu, Eric D. Hsi, Hua You, Jooryung Huh, Maurilio Ponzoni, Andrés J.M. Ferreri, Michael B. Møller, Benjamin M. Parsons, Fredrick Hagemeister, J. Han van Krieken, Miguel A. Piris, Jane N. Winter, Yong Li, Bing Xu, Phillip Liu and Ken H. Young
    Mol Cancer Res February 1 2021 19 (2) 249-260; DOI:10.1158/1541-7786.MCR-20-0466

  • Cancer Genes and Networks
    FBW7 Inhibits Myeloid Differentiation in Acute Myeloid Leukemia via GSK3-Dependent Ubiquitination of PU.1
    Mukul Mishra, Gatha Thacker, Akshay Sharma, Anil Kumar Singh, Vishal Upadhyay, Sabyasachi Sanyal, Shailendra Prasad Verma, Anil Kumar Tripathi, Madan Lal Brahma Bhatt and Arun Kumar Trivedi
    Mol Cancer Res February 1 2021 19 (2) 261-273; DOI:10.1158/1541-7786.MCR-20-0268

Cell Fate Decisions

  • Cell Fate Decisions
    A Role for the Autophagic Receptor, SQSTM1/p62, in Trafficking NF-κB/RelA to Nucleolar Aggresomes
    Ian T. Lobb, Pierre Morin, Kirsty Martin, Hazel C. Thoms, Jimi C. Wills, Xhordi Lleshi, Karl C.F. Olsen, Rory R. Duncan and Lesley A. Stark
    Mol Cancer Res February 1 2021 19 (2) 274-287; DOI:10.1158/1541-7786.MCR-20-0336

  • Cell Fate Decisions
    Intraperitoneal Oil Application Causes Local Inflammation with Depletion of Resident Peritoneal Macrophages
    Elisenda Alsina-Sanchis, Ronja Mülfarth, Iris Moll, Carolin Mogler, Juan Rodriguez-Vita and Andreas Fischer
    Mol Cancer Res February 1 2021 19 (2) 288-300; DOI:10.1158/1541-7786.MCR-20-0650

Genome Maintenance

  • Genome Maintenance
    SLX4IP Promotes Telomere Maintenance in Androgen Receptor–Independent Castration-Resistant Prostate Cancer through ALT-like Telomeric PML Localization
    Tawna L. Mangosh, Wisam N. Awadallah, Magdalena M. Grabowska and Derek J. Taylor
    Mol Cancer Res February 1 2021 19 (2) 301-316; DOI:10.1158/1541-7786.MCR-20-0314

Signal Transduction and Functional Imaging

  • Signal Transduction and Functional Imaging
    SHOC2 Is a Critical Modulator of Sensitivity to EGFR–TKIs in Non–Small Cell Lung Cancer Cells
    Hideki Terai, Junko Hamamoto, Katsura Emoto, Takeshi Masuda, Tadashi Manabe, Satoshi Kuronuma, Keigo Kobayashi, Keita Masuzawa, Shinnosuke Ikemura, Sohei Nakayama, Ichiro Kawada, Yusuke Suzuki, Osamu Takeuchi, Yukio Suzuki, Sumio Ohtsuki, Hiroyuki Yasuda, Kenzo Soejima and Koichi Fukunaga
    Mol Cancer Res February 1 2021 19 (2) 317-328; DOI:10.1158/1541-7786.MCR-20-0664

  • Signal Transduction and Functional Imaging
    Breast Tumor Kinase (Brk/PTK6) Mediates Advanced Cancer Phenotypes via SH2-Domain Dependent Activation of RhoA and Aryl Hydrocarbon Receptor (AhR) Signaling
    Amy R. Dwyer, Carlos Perez Kerkvliet, Raisa I. Krutilina, Hilaire C. Playa, Deanna N. Parke, Warner A. Thomas, Branden A. Smeester, Branden S. Moriarity, Tiffany N. Seagroves and Carol A. Lange
    Mol Cancer Res February 1 2021 19 (2) 329-345; DOI:10.1158/1541-7786.MCR-20-0295

Tumor Microenvironment and Immunobiology

  • Tumor Microenvironment and Immunobiology
    Studying Immunotherapy Resistance in a Melanoma Autologous Humanized Mouse Xenograft
    J. Jason Morton, Nathaniel Alzofon, Stephen B. Keysar, Tugs-Saikhan Chimed, Julie Reisinger, Loni Perrenoud, Phuong N. Le, Cera Nieto, Karina Gomez, Bettina Miller, Randi Yeager, Dexiang Gao, Aik-Choon Tan, Hilary Somerset, Theresa Medina, Xiao-Jing Wang, Jing H. Wang, William Robinson, Dennis R. Roop, Rene Gonzalez and Antonio Jimeno
    Mol Cancer Res February 1 2021 19 (2) 346-357; DOI:10.1158/1541-7786.MCR-20-0686

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Molecular Cancer Research: 19 (2)
February 2021
Volume 19, Issue 2
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Issue Highlights

  • Intraperitoneal Oil Application Causes Local Inflammation with Depletion of Resident Peritoneal Macrophages
  • Transcriptomic Analysis of Diffuse Intrinsic Pontine Glioma (DIPG) Identifies a Targetable ALDH-Positive Subset of Highly Tumorigenic Cancer Stem-like Cells
  • Aggressive B-cell Lymphoma with MYC/TP53 Dual Alterations Displays Distinct Clinicopathobiological Features and Response to Novel Targeted Agents
  • Breast Tumor Kinase (Brk/PTK6) Mediates Advanced Cancer Phenotypes via SH2-Domain Dependent Activation of RhoA and Aryl Hydrocarbon Receptor (AhR) Signaling

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  • Highlights
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  • Cancer Genes and Networks
  • Cell Fate Decisions
  • Genome Maintenance
  • Signal Transduction and Functional Imaging
  • Tumor Microenvironment and Immunobiology
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  • Evolving Evolvability and the Origins of Lethal Cancer
  • Vincristine Depletes Microtubule-Bound MYC in Mitosis
  • Stromal Regulation of Breast Cancer Invasion
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Molecular Cancer Research
eISSN: 1557-3125
ISSN: 1541-7786

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