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Molecular Cancer Research
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Cell Adhesion Molecules in Plasticity and Metastasis

Jessica A. Smart, Julia E. Oleksak and Edward J. Hartsough
Jessica A. Smart
1Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania.
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  • ORCID record for Jessica A. Smart
Julia E. Oleksak
2Graduate School of Biomedical Sciences and Professional Studies, Drexel University College of Medicine, Philadelphia, Pennsylvania.
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Edward J. Hartsough
1Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania.
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  • For correspondence: ejh329@drexel.edu
DOI: 10.1158/1541-7786.MCR-20-0595 Published January 2021
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Abstract

Prior to metastasis, modern therapeutics and surgical intervention can provide a favorable long-term survival for patients diagnosed with many types of cancers. However, prognosis is poor for patients with metastasized disease. Melanoma is the deadliest form of skin cancer, yet in situ and localized, thin melanomas can be biopsied with little to no postsurgical follow-up. However, patients with metastatic melanoma require significant clinical involvement and have a 5-year survival of only 34% to 52%, largely dependent on the site of colonization. Melanoma metastasis is a multi-step process requiring dynamic changes in cell surface proteins regulating adhesiveness to the extracellular matrix (ECM), stroma, and other cancer cells in varied tumor microenvironments. Here we will highlight recent literature to underscore how cell adhesion molecules (CAM) contribute to melanoma disease progression and metastasis.

Footnotes

  • Mol Cancer Res 2021;19:25–37

  • Received July 6, 2020.
  • Revision received September 8, 2020.
  • Accepted September 25, 2020.
  • Published first October 1, 2020.
  • ©2020 American Association for Cancer Research.
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Molecular Cancer Research: 19 (1)
January 2021
Volume 19, Issue 1
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Cell Adhesion Molecules in Plasticity and Metastasis
Jessica A. Smart, Julia E. Oleksak and Edward J. Hartsough
Mol Cancer Res January 1 2021 (19) (1) 25-37; DOI: 10.1158/1541-7786.MCR-20-0595

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Cell Adhesion Molecules in Plasticity and Metastasis
Jessica A. Smart, Julia E. Oleksak and Edward J. Hartsough
Mol Cancer Res January 1 2021 (19) (1) 25-37; DOI: 10.1158/1541-7786.MCR-20-0595
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  • Article
    • Abstract
    • Introduction
    • Phenotype Switch
    • Integrins
    • Cadherins
    • Immunoglobulin-containing CAMs
    • Connexins
    • Mucins
    • CAMs and Immune Checkpoint Inhibitors
    • Conclusion
    • Authors' Disclosures
    • Acknowledgments
    • Footnotes
    • References
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Molecular Cancer Research
eISSN: 1557-3125
ISSN: 1541-7786

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