Molecular Cancer Research: 18 (9)

Highlights

Highlights

Selected Articles from This Issue

Mol Cancer Res September 1 2020 18 (9) 1255-1256;

Review

Review | AuthorChoice

Epithelial–Mesenchymal Transition Programs and Cancer Stem Cell Phenotypes: Mediators of Breast Cancer Therapy Resistance

Alex J. Gooding and William P. Schiemann

Mol Cancer Res September 1 2020 18 (9) 1257-1270; DOI:10.1158/1541-7786.MCR-20-0067

Rapid Impact

Rapid Impact

Bacterial SOS Genes mucAB/umuDC Promote Mouse Tumors by Activating Oncogenes Nedd9/Aurkb via a miR-145 Sponge

Hiroshi Tanooka, Ayako Inoue, Ryou-u Takahashi, Kouichi Tatsumi, Kazuo Fujikawa, Tetsuji Nagao, Masamichi Ishiai, Fumiko Chiwaki, Kazuhiko Aoyagi, Hiroki Sasaki and Takahiro Ochiya

Mol Cancer Res September 1 2020 18 (9) 1271-1277; DOI:10.1158/1541-7786.MCR-20-0137

Cancer “-omics”

Cancer “-omics” | AuthorChoice

Metastasis-Specific Gene Expression in Autochthonous and Allograft Mouse Mammary Tumor Models: Stratification and Identification of Targetable Signatures

Christina Ross, Karol Szczepanek, Maxwell Lee, Howard Yang, Cody J. Peer, Jessica Kindrick, Priya Shankarappa, Zhi-Wei Lin, Jack D. Sanford, William D. Figg and Kent W. Hunter

Mol Cancer Res September 1 2020 18 (9) 1278-1289; DOI:10.1158/1541-7786.MCR-20-0046
Cancer “-omics”

Single-Cell Transcriptomics Analysis Identifies Nuclear Protein 1 as a Regulator of Docetaxel Resistance in Prostate Cancer Cells

Patricia M. Schnepp, Greg Shelley, Jinlu Dai, Nicole Wakim, Hui Jiang, Atsushi Mizokami and Evan T. Keller

Mol Cancer Res September 1 2020 18 (9) 1290-1301; DOI:10.1158/1541-7786.MCR-20-0051
Cancer “-omics”

Oncogenic Gene-Expression Programs in Leiomyosarcoma and Characterization of Conventional, Inflammatory, and Uterogenic Subtypes

Matthew L. Hemming, Changyu Fan, Chandrajit P. Raut, George D. Demetri, Scott A. Armstrong, Ewa Sicinska and Suzanne George

Mol Cancer Res September 1 2020 18 (9) 1302-1314; DOI:10.1158/1541-7786.MCR-20-0197
Cancer “-omics”

Clinical Characteristics and Exploratory Genomic Analyses of Germline BRCA1 or BRCA2 Mutations in Breast Cancer

Sehhoon Park, Eunjin Lee, Seri Park, Sohee Lee, Seok Jin Nam, Seok Won Kim, Jeong Eon Lee, Jong-Han Yu, Ji-Yeon Kim, Jin Seok Ahn, Young-Hyuck Im, Woong-Yang Park, Kyunghee Park and Yeon Hee Park

Mol Cancer Res September 1 2020 18 (9) 1315-1325; DOI:10.1158/1541-7786.MCR-19-1108

Cancer Genes and Networks

Cancer Genes and Networks

Telomere DNA Damage Signaling Regulates Prostate Cancer Tumorigenesis

Jianchun Wu and David L. Crowe

Mol Cancer Res September 1 2020 18 (9) 1326-1339; DOI:10.1158/1541-7786.MCR-19-1129
Cancer Genes and Networks

Circadian Oscillations Persist in Cervical and Esophageal Cancer Cells Displaying Decreased Expression of Tumor-Suppressing Circadian Clock Genes

Pauline J. van der Watt, Laura C. Roden, Kate T. Davis, M. Iqbal Parker and Virna D. Leaner

Mol Cancer Res September 1 2020 18 (9) 1340-1353; DOI:10.1158/1541-7786.MCR-19-1074

Cell Fate Decisions

Cell Fate Decisions

DNA Replication Stress Induced by Trifluridine Determines Tumor Cell Fate According to p53 Status

Yuki Kataoka, Makoto Iimori, Ryo Fujisawa, Tomomi Morikawa-Ichinose, Shinichiro Niimi, Takeshi Wakasa, Hiroshi Saeki, Eiji Oki, Daisuke Miura, Toshiki Tsurimoto, Yoshihiko Maehara and Hiroyuki Kitao

Mol Cancer Res September 1 2020 18 (9) 1354-1366; DOI:10.1158/1541-7786.MCR-19-1051

Genome Maintenance

Genome Maintenance

HDAC3 Is Required for XPC Recruitment and Nucleotide Excision Repair of DNA Damage Induced by UV Irradiation

Koji Nishimoto, Hiroyuki Niida, Chiharu Uchida, Tatsuya Ohhata, Kyoko Kitagawa, Akira Motegi, Takafumi Suda and Masatoshi Kitagawa

Mol Cancer Res September 1 2020 18 (9) 1367-1378; DOI:10.1158/1541-7786.MCR-20-0214

Metabolism

Metabolism

Mitochondria Participate in Chemoresistance to Cisplatin in Human Ovarian Cancer Cells

Luca X. Zampieri, Debora Grasso, Caroline Bouzin, Davide Brusa, Rodrigue Rossignol and Pierre Sonveaux

Mol Cancer Res September 1 2020 18 (9) 1379-1391; DOI:10.1158/1541-7786.MCR-19-1145

Signal Transduction and Functional Imaging

Signal Transduction and Functional Imaging

PRAS40 Phosphorylation Correlates with Insulin-Like Growth Factor-1 Receptor-Induced Resistance to Epidermal Growth Factor Receptor Inhibition in Head and Neck Cancer Cells

Michael I. Dougherty, Christine E. Lehman, Adam Spencer, Rolando E. Mendez, Abel P. David, Linnea E. Taniguchi, Julie Wulfkuhle, Emanuel F. Petricoin, Daniel Gioeli and Mark J. Jameson

Mol Cancer Res September 1 2020 18 (9) 1392-1401; DOI:10.1158/1541-7786.MCR-19-0592

Tumor Microenvironment and Immunobiology

Tumor Microenvironment and Immunobiology

A TGFβ-Dependent Stromal Subset Underlies Immune Checkpoint Inhibitor Efficacy in DNA Mismatch Repair–Deficient/Microsatellite Instability-High Colorectal Cancer

Eisei Endo, Hirokazu Okayama, Katsuharu Saito, Shotaro Nakajima, Leo Yamada, Daisuke Ujiie, Koji Kase, Shotaro Fujita, Hisahito Endo, Wataru Sakamoto, Motonobu Saito, Zenichiro Saze, Tomoyuki Momma, Shinji Ohki, Kosaku Mimura and Koji Kono

Mol Cancer Res September 1 2020 18 (9) 1402-1413; DOI:10.1158/1541-7786.MCR-20-0308
Tumor Microenvironment and Immunobiology

Stromal CAVIN1 Controls Prostate Cancer Microenvironment and Metastasis by Modulating Lipid Distribution and Inflammatory Signaling

Jin-Yih Low, W. Nathaniel Brennen, Alan K. Meeker, Elina Ikonen, Brian W. Simons and Marikki Laiho

Mol Cancer Res September 1 2020 18 (9) 1414-1426; DOI:10.1158/1541-7786.MCR-20-0364
Tumor Microenvironment and Immunobiology

Tumor Endothelial Cell–Mediated Antigen-Specific T-cell Suppression via the PD-1/PD-L1 Pathway

Kazuhiro Taguchi, Takashi Onoe, Tomoaki Yoshida, Yoshinori Yamashita, Yuka Tanaka and Hideki Ohdan

Mol Cancer Res September 1 2020 18 (9) 1427-1440; DOI:10.1158/1541-7786.MCR-19-0897

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Table of Contents

Highlights

Review

Rapid Impact

Cancer “-omics”

Cancer Genes and Networks

Cell Fate Decisions

Genome Maintenance

Metabolism

Signal Transduction and Functional Imaging

Tumor Microenvironment and Immunobiology

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