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Molecular Cancer Research
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Nucleostemin Modulates Outcomes of Hepatocellular Carcinoma via a Tumor Adaptive Mechanism to Genomic Stress

Junying Wang, Daniel J. McGrail, Parnit K. Bhupal, Wen Zhang, Kuan-Yu Lin, Yi-Hsuan Ku, Tao Lin, Hongfu Wu, Kyle C. Tsai, Kaiyi Li, Cheng-Yuan Peng, Milton J. Finegold, Shiaw-Yih Lin and Robert Y.L. Tsai
Junying Wang
1Institute of Biosciences and Technology, Texas A&M University, Houston, Texas.
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Daniel J. McGrail
2Department of Systems Biology, MD Anderson Cancer Center, Houston, Texas.
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Parnit K. Bhupal
1Institute of Biosciences and Technology, Texas A&M University, Houston, Texas.
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Wen Zhang
1Institute of Biosciences and Technology, Texas A&M University, Houston, Texas.
3Department of Integrative Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
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Kuan-Yu Lin
1Institute of Biosciences and Technology, Texas A&M University, Houston, Texas.
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Yi-Hsuan Ku
1Institute of Biosciences and Technology, Texas A&M University, Houston, Texas.
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Tao Lin
1Institute of Biosciences and Technology, Texas A&M University, Houston, Texas.
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Hongfu Wu
1Institute of Biosciences and Technology, Texas A&M University, Houston, Texas.
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Kyle C. Tsai
4Michael E. DeBakey High School for Health Professions, Houston, Texas.
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Kaiyi Li
5Department of Surgery, Baylor College of Medicine, Houston, Texas.
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Cheng-Yuan Peng
6Division of Hepatogastroenterology, Department of Internal Medicine, China Medical University Hospital, School of Medicine, China Medical University, Taichung, Taiwan.
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Milton J. Finegold
7Department of Pathology & Immunology, Baylor College of Medicine, Houston, Texas.
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Shiaw-Yih Lin
2Department of Systems Biology, MD Anderson Cancer Center, Houston, Texas.
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Robert Y.L. Tsai
1Institute of Biosciences and Technology, Texas A&M University, Houston, Texas.
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  • ORCID record for Robert Y.L. Tsai
  • For correspondence: robtsai@tamu.edu
DOI: 10.1158/1541-7786.MCR-19-0777 Published May 2020
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Total183680265

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Article Information

Volume 18, Issue 5, pp. 723-734

DOI 
https://doi.org/10.1158/1541-7786.MCR-19-0777
PubMed 
32051231

Published By 
American Association for Cancer Research
Print ISSN 
1541-7786
Online ISSN 
1557-3125
History 
  • Received August 1, 2019
  • Revision received January 3, 2020
  • Accepted February 5, 2020
  • Published first February 12, 2020.

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  • Previous version (February 12, 2020 - 06:27).
  • Previous version (March 4, 2020 - 06:23).
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Copyright & Usage 
©2020 American Association for Cancer Research.

Author Information

  1. Junying Wang1,
  2. Daniel J. McGrail2,#,
  3. Parnit K. Bhupal1,#,
  4. Wen Zhang1,3,
  5. Kuan-Yu Lin1,
  6. Yi-Hsuan Ku1,
  7. Tao Lin1,
  8. Hongfu Wu1,
  9. Kyle C. Tsai4,
  10. Kaiyi Li5,
  11. Cheng-Yuan Peng6,
  12. Milton J. Finegold7,
  13. Shiaw-Yih Lin2, and
  14. Robert Y.L. Tsai1,*
  1. 1Institute of Biosciences and Technology, Texas A&M University, Houston, Texas.
  2. 2Department of Systems Biology, MD Anderson Cancer Center, Houston, Texas.
  3. 3Department of Integrative Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
  4. 4Michael E. DeBakey High School for Health Professions, Houston, Texas.
  5. 5Department of Surgery, Baylor College of Medicine, Houston, Texas.
  6. 6Division of Hepatogastroenterology, Department of Internal Medicine, China Medical University Hospital, School of Medicine, China Medical University, Taichung, Taiwan.
  7. 7Department of Pathology & Immunology, Baylor College of Medicine, Houston, Texas.
  1. ↵*Corresponding Author:
    Robert Y.L. Tsai, Texas A&M Health Science Center, 2121 W. Holcombe Blvd., Rm 517, Houston, TX 77030. Phone: 713-677-7690; Fax: 713-677-7512; E-mail: robtsai{at}tamu.edu
  1. ↵#D.J. McGrail and P.K. Bhupal contribute equally to this article.

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Molecular Cancer Research: 18 (5)
May 2020
Volume 18, Issue 5
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Nucleostemin Modulates Outcomes of Hepatocellular Carcinoma via a Tumor Adaptive Mechanism to Genomic Stress
Junying Wang, Daniel J. McGrail, Parnit K. Bhupal, Wen Zhang, Kuan-Yu Lin, Yi-Hsuan Ku, Tao Lin, Hongfu Wu, Kyle C. Tsai, Kaiyi Li, Cheng-Yuan Peng, Milton J. Finegold, Shiaw-Yih Lin and Robert Y.L. Tsai
Mol Cancer Res May 1 2020 (18) (5) 723-734; DOI: 10.1158/1541-7786.MCR-19-0777

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Nucleostemin Modulates Outcomes of Hepatocellular Carcinoma via a Tumor Adaptive Mechanism to Genomic Stress
Junying Wang, Daniel J. McGrail, Parnit K. Bhupal, Wen Zhang, Kuan-Yu Lin, Yi-Hsuan Ku, Tao Lin, Hongfu Wu, Kyle C. Tsai, Kaiyi Li, Cheng-Yuan Peng, Milton J. Finegold, Shiaw-Yih Lin and Robert Y.L. Tsai
Mol Cancer Res May 1 2020 (18) (5) 723-734; DOI: 10.1158/1541-7786.MCR-19-0777
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